LAP3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL562383	0.57	7/20
SCHEMBL244193	0.56	7/20
SCHEMBL289159	0.55	7/20
Hydrochloric Acid (SCHEMBL540968)	0.54	7/20
Medronic Acid (SCHEMBL242844)	0.59	6/20
Phosphoric Acid (SCHEMBL183216)	0.57	6/20
Amphetamine (SCHEMBL113682)	0.63	5/20
Dextroamphetamine (SCHEMBL547496)	0.63	5/20
SCHEMBL206196	0.57	5/20
SCHEMBL57183	0.54	5/20
SCHEMBL445039	0.49	5/20
SCHEMBL206787	0.47	5/20
SCHEMBL43394	0.47	5/20
SCHEMBL233492	0.46	5/20
SCHEMBL417728	0.44	5/20
SCHEMBL462556	0.44	5/20
SCHEMBL495567	0.43	5/20
Glyphosate (SCHEMBL18900)	0.38	5/20
Glyphosate (SCHEMBL271541)	0.38	5/20
SCHEMBL289232	0.62	4/20

Clinical trials — most relevant to LAP3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Strict Blood Pressure Control and ACE-Inhibition on Progression of Chronic Renal Failure in Pediatric Patients	PHASE3	COMPLETED
A Valsartan 80 Mg-Referenced, Therapeutic Exploratory Clinical Study to Evaluate the Antihypertensive Efficacy of Fimasartan 30 mg During 24 Hours in Patients With Mild to Moderate Essential Hypertension	PHASE2	COMPLETED
18F-DCFPyL PET/CT in High Risk and Recurrent Prostate Cancer	PHASE2	ACTIVE_NOT_RECRUITING
18F-DCFBC PET/CT in Prostate Cancer	EARLY_PHASE1	COMPLETED
The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism	EARLY_PHASE1	UNKNOWN
Institution of an Italian Multicenter Database of Patients Affected by Diseases of Phosphate Metabolism	nan	NOT_YET_RECRUITING
Lipa Gene Mutation in PED-LIPIGEN (Pediatric FH Subjects)	nan	UNKNOWN
Study of Tissue, Blood, and Urine Samples From Patients With Advanced Prostate Cancer	nan	UNKNOWN
Ovarian Reserve and Matrix Metalloproteinases	nan	COMPLETED
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Prostate Cancer Antigen 3 (PCA-3) Gene Project	nan	COMPLETED
Clearance of Vasoactive Metabolites With Blood Purification	nan	RECRUITING
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease	nan	UNKNOWN
Screening of Lysosomal Storage Disorders Diseases in Minority Groups	nan	UNKNOWN
Acute Pancreatitis Targets (APT) Study	nan	COMPLETED
A Prospective, Single-centre，Single-blinded Study of PROUD for Prostate Carcinoma Diagnosis	nan	UNKNOWN
Pharmacokinetics of Low Molecular Weight Heparin in Cancer Patients	nan	COMPLETED
PSMA Expression and PSMA PET Imaging in Soft Tissue Sarcomas and Urothelial Cell Carcinomas	nan	COMPLETED
Influence of Genetic Polymorphisms on Ventricular Structure and Function in Patients With Single Ventricle Anatomy	nan	COMPLETED
The Natural History of Alpha-Mannosidosis	nan	COMPLETED
The V-Wave Shunt: FIM Safety and Feasibility Study	nan	COMPLETED
Neutral Endopeptidase for Early Detection of Acute Kidney Injury After Cardiac Surgery	nan	COMPLETED
Genetic Variations That Increase the Risk for Calcium Kidney Stones: a Family-based Study	nan	COMPLETED
The Effect of Monoallelic Variants in the ALPL Gene on the Natural Course of Hypophosphatasia in Russia	nan	RECRUITING
Perfusion - Pressure - Creatinine Trial	nan	COMPLETED
The Predictive Role of Urinary Proteomics in Blood Pressure Response of Obese Hypertensive Treated With Irbesartan or Eplerenone.	nan	UNKNOWN
Rab 32 Gene Polymorphisms as a Prognostic Factor in Leprosy Patients	nan	RECRUITING
Influence of Statins in Artery Aneurysms	nan	UNKNOWN
Clinical Evaluation of the PROGENSA(Registered Trademark) Prostate Cancer Gene 3 (PCA3) Assay in Men With a Previous Negative Biopsy Result	nan	COMPLETED
Family Blood Pressure Program - HyperGEN	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a LAP3 binder may also engage these)

Protein	Name	Similarity
P00727	—	1.000	P00727 →
Q68FS4	—	1.000	Q68FS4 →
P28839	—	1.000	P28839 →
Q9CPY7	—	0.999	Q9CPY7 →
Q5XGB9	—	0.997	Q5XGB9 →
Q5V9F0	—	0.966	Q5V9F0 →
P30184	—	0.966	P30184 →
Q328S1	—	0.965	Q328S1 →
A7ZVE0	—	0.965	A7ZVE0 →
P68767	—	0.965	P68767 →
B6I2H3	—	0.965	B6I2H3 →
Q3YU89	—	0.965	Q3YU89 →
Q0SXK0	—	0.965	Q0SXK0 →
B7NUH4	—	0.965	B7NUH4 →
B7LCX0	—	0.965	B7LCX0 →
Q5E7T8	—	0.965	Q5E7T8 →
A1SRZ1	—	0.964	A1SRZ1 →
A9MET9	—	0.964	A9MET9 →
B7MSZ3	—	0.964	B7MSZ3 →
A1AJG3	—	0.964	A1AJG3 →
B5Z3L7	—	0.964	B5Z3L7 →
Q1R2Z4	—	0.964	Q1R2Z4 →
Q9NWU1	—	0.964	Q9NWU1 →
A3QBG2	—	0.964	A3QBG2 →
Q83P64	—	0.964	Q83P64 →
Q15PX4	—	0.964	Q15PX4 →
Q6NSR8	—	0.964	Q6NSR8 →
A9N680	—	0.964	A9N680 →
B5BKS6	—	0.964	B5BKS6 →
B4F2N1	—	0.964	B4F2N1 →