Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30542404 | 0.86 | KMT2A (0.48) | LMNACHRM2ADRA2ACYP2D6TSHR | |
| SCHEMBL25373086 | 0.86 | KMT2A (0.48) | LMNACHRM2ADRA2ACYP2D6TSHR | |
| SCHEMBL30542372 | 0.86 | KMT2A (0.48) | LMNACHRM2ADRA2ACYP2D6TSHR | |
| SCHEMBL541133 | 0.82 | MEN1 (0.63) | CYP2D6KMT2AMAPTMEN1NPSR1 | |
| SCHEMBL31398594 | 0.81 | HSD11B1 (0.48) | KMT2AMAPTMEN1NPSR1SMN1; SMN2 | |
| SCHEMBL17572223 | 0.81 | MEN1 (0.66) | KMT2AMAPTMEN1NPSR1SMN1; SMN2 | |
| SCHEMBL4134071 | 0.81 | MEN1 (0.55) | KMT2AMAPTMEN1NPSR1SMN1; SMN2 | |
| SCHEMBL11363329 | 0.79 | MEN1 (0.53) | ADRA2ADRD1KMT2AMAPTMEN1 | |
| SCHEMBL2434340 | 0.78 | MEN1 (0.58) | CYP2D6TSHRKMT2AMEN1NPSR1 | |
| SCHEMBL29319091 | 0.78 | MEN1 (0.55) | KMT2AMAPTMEN1NPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4255432-A | ANTIHYPERTENSIVE AGENTS, ANTIHISTAMINES, BRONCHODILATOR AGENTS, ANTIVASOSPASTIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1981-03-10 | — | — | US | disclosed |
| US-4244961-A | 1-Oxa-3,8-diazaspiro[4.5]decan-2-ones antihypertensive agents | SYNTEX (U.S.A.) INC. (US) | 1981-01-13 | — | — | US | disclosed |