Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A | P37088 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | THPO | P40225 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 2/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1136823 | 0.72 | SCNN1A (0.48) | SCNN1AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL3155690 | 0.72 | SCNN1A (0.43) | SCNN1AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL3155710 | 0.72 | SCNN1A (0.43) | SCNN1AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL15624982 | 0.65 | PLAU (0.45) | SCNN1AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL12644497 | 0.65 | SCNN1A (0.43) | SCNN1AALDH1A1KDM4EHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL1136717 | 0.64 | SCNN1A (0.42) | SCNN1AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL15630619 | 0.64 | SCNN1A (0.46) | SCNN1AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL24876859 | 0.63 | PLAU (0.56) | SCNN1AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL15624920 | 0.63 | PLAU (0.52) | SCNN1AALDH1A1KDM4EHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL15610412 | 0.63 | SCNN1A (0.46) | SCNN1AALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2332933-A1 | Epithelial sodium channel (ENaC) inhibitors | Novartis AG (CH) | 2011-06-15 | — | — | EP | disclosed |
| EP-2155721-B1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-02-23 | — | — | EP | disclosed |