Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A | P37088 | 13/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 6/20 | 0.41 |
| ▸ | GLA | P06280 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.41 |
| ▸ | THPO | P40225 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 2/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3155710 | 1.00 | SCNN1A (0.43) | SCNN1AALDH1A1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL1136823 | 0.82 | SCNN1A (0.48) | SCNN1AALDH1A1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL12644497 | 0.81 | SCNN1A (0.43) | SCNN1AALDH1A1NPC1SMN1; SMN2RAB9A | |
| Hydrochloric Acid SCHEMBL1136717 | 0.81 | SCNN1A (0.42) | SCNN1AALDH1A1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL1136831 | 0.72 | SCNN1A (0.41) | SCNN1AALDH1A1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL15624920 | 0.70 | PLAU (0.52) | SCNN1AALDH1A1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL12863454 | 0.70 | SCNN1A (0.31) | SCNN1AALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL1136994 | 0.69 | SCNN1A (0.46) | SCNN1AALDH1A1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL15610280 | 0.69 | SCNN1A (0.40) | SCNN1AALDH1A1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL3311556 | 0.69 | SCNN1A (0.50) | SCNN1AALDH1A1NPC1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318935-B2 | Organic compounds 75074 | NOVARTIS AG (CH) | 2012-11-27 | — | — | US | disclosed |
| US-20100105660-A1 | ORGANIC COMPOUNDS75074 | NOVARTIS AG (CH) | 2010-04-29 | — | — | US | disclosed |
| EP-2155721-A1 | ORGANIC COMPOUNDS | Novartis Ag (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008135557-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2008-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105660-A1 | ORGANIC COMPOUNDS75074 | SCNN1A, TRPM4, TRPV4 | SCNN1A 1/4885ALDH1A1 1031/4885NPC1 1151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.