Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | BRD4 | O60885 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.50 |
| ▸ | BRD2 | P25440 | 1/20 | 0.50 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.50 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25612867 | 0.87 | CNR2 (0.62) | NOTUMSMN1; SMN2TP53KDM4EMEN1 | |
| SCHEMBL11608258 | 0.83 | KDM4E (0.47) | SMN1; SMN2TP53HTTKDM4EPOLB | |
| SCHEMBL28069907 | 0.83 | NOTUM (0.62) | NOTUMSMN1; SMN2TP53HTTKDM4E | |
| SCHEMBL12502932 | 0.79 | NOTUM (0.55) | NOTUMKDM4EBRD4MAPK14BRD2 | |
| SCHEMBL4685054 | 0.78 | MAPK14 (0.52) | NOTUMSMN1; SMN2TP53HTTKDM4E | |
| SCHEMBL6652306 | 0.78 | MAPK14 (0.60) | NOTUMSMN1; SMN2TP53HTTKDM4E | |
| SCHEMBL12502722 | 0.76 | NOTUM (0.58) | NOTUMSMN1; SMN2KDM4EPOLBBRD4 | |
| SCHEMBL29639001 | 0.76 | NOTUM (0.42) | NOTUMSMN1; SMN2TP53HTTKDM4E | |
| SCHEMBL16509736 | 0.75 | BRD4 (0.56) | SMN1; SMN2TP53HTTKDM4ECYP2D6 | |
| SCHEMBL3175610 | 0.75 | NOTUM (0.46) | NOTUMSMN1; SMN2TP53HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737451-B1 | MONOCYCLIC HETEROCYCLES AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-02-23 | — | — | EP | disclosed |