Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.62 |
| ▸ | BRD4 | O60885 | 2/20 | 0.51 |
| ▸ | BRD2 | P25440 | 1/20 | 0.51 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.51 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | VEGFA | P15692 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12502932 | 0.83 | NOTUM (0.55) | NOTUMBRD4BRD2BRD3BRDT | |
| SCHEMBL12502722 | 0.83 | NOTUM (0.58) | NOTUMBRD4BRD2BRD3BRDT | |
| SCHEMBL20873304 | 0.83 | NOTUM (0.60) | NOTUMBRD4BRD2BRD3BRDT | |
| SCHEMBL1137261 | 0.83 | NOTUM (0.56) | NOTUMBRD4BRD2BRD3BRDT | |
| SCHEMBL1137531 | 0.80 | BRD4 (0.70) | NOTUMBRD4BRD2BRD3BRDT | |
| Hydrochloric Acid SCHEMBL11454825 | 0.79 | BRD4 (0.68) | NOTUMBRD4BRD2BRD3BRDT | |
| SCHEMBL11439685 | 0.78 | NOTUM (0.68) | NOTUMBRD4BRD2BRD3BRDT | |
| SCHEMBL14846520 | 0.78 | MAPK14 (0.57) | NOTUMBRD4BRD2BRD3BRDT | |
| SCHEMBL3492700 | 0.77 | NOTUM (1.00) | NOTUMBRD4BRD2BRD3BRDT | |
| SCHEMBL18043946 | 0.76 | NOTUM (0.49) | NOTUMBRD4BRD2BRD3BRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103608346-B | As the 7-naphthyridine derivatives of hypoxia inducible factor (HIF) hydroxylase inhibitors | 菲布罗根有限公司 | 2016-06-15 | — | — | CN | disclosed |