Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11330634 | 0.77 | RAB9A (0.40) | LMNACA12CA1CA2CA7 | |
| SCHEMBL4244888 | 0.76 | CA12 (0.46) | LMNACYP1A2CYP3A4MAOACA12 | |
| SCHEMBL11329885 | 0.74 | MAPT (0.44) | LMNACYP1A2CYP3A4CA2MAPT | |
| SCHEMBL1464834 | 0.73 | MAPK1 (0.69) | LMNAMAPTRAB9ATSHRL3MBTL1 | |
| SCHEMBL1640023 | 0.73 | RAB9A (0.73) | LMNACYP1A2CYP3A4MAPTRAB9A | |
| SCHEMBL29394052 | 0.73 | RAB9A (0.73) | LMNACYP1A2CYP3A4MAPTRAB9A | |
| SCHEMBL29518299 | 0.72 | CA12 (0.47) | LMNACYP1A2CYP3A4MAOACA12 | |
| SCHEMBL29426140 | 0.72 | CA12 (0.47) | LMNACYP1A2CYP3A4MAOACA12 | |
| SCHEMBL1751226 | 0.71 | MAPT (0.59) | LMNACA12CA1CA2CA7 | |
| SCHEMBL20826393 | 0.70 | MAPT (0.64) | LMNAMAPTRAB9ATSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4254118-A | 1-Oxo-5H-pyrimido[2,1-c][1,4]benzthiazine-2-carboxylic acid esters | AYERST, MCKENNA & HARRISON INC. (CA) | 1981-03-03 | — | — | US | disclosed |