Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CCR3 | P51677 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17101429 | 0.85 | CYP2D6 (0.51) | OPRL1POLBCCR3CYP2D6CHRM2 | |
| SCHEMBL596787 | 0.84 | CYP2D6 (0.55) | OPRL1POLBCYP2D6CHRM2CHRM3 | |
| SCHEMBL16973869 | 0.83 | OPRL1 (0.59) | OPRL1POLBCCR3CYP2D6CHRM2 | |
| SCHEMBL4484154 | 0.78 | OPRL1 (0.61) | OPRL1POLBCCR3CYP2D6CHRM2 | |
| SCHEMBL11362333 | 0.77 | MEN1 (0.54) | ALDH1A1KMT2ASIGMAR1MEN1 | |
| SCHEMBL1147211 | 0.76 | OPRL1 (0.63) | OPRL1POLBCCR3CYP2D6CHRM2 | |
| SCHEMBL31334693 | 0.76 | NPFFR1 (0.53) | OPRL1POLBCCR3CYP2D6CHRM2 | |
| SCHEMBL653329 | 0.76 | OPRL1 (0.67) | OPRL1POLBCCR3CYP2D6CHRM2 | |
| SCHEMBL28548988 | 0.76 | OPRL1 (0.71) | OPRL1POLBCCR3CYP2D6CHRM2 | |
| Hydrochloric Acid SCHEMBL25235306 | 0.75 | POLB (0.64) | OPRL1POLBCCR3CYP2D6CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4255432-A | ANTIHYPERTENSIVE AGENTS, ANTIHISTAMINES, BRONCHODILATOR AGENTS, ANTIVASOSPASTIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1981-03-10 | — | — | US | disclosed |
| US-4244961-A | 1-Oxa-3,8-diazaspiro[4.5]decan-2-ones antihypertensive agents | SYNTEX (U.S.A.) INC. (US) | 1981-01-13 | — | — | US | disclosed |