Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.53 |
| ▸ | NPC1 | O15118 | 8/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SCD | O00767 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11376099 | 0.87 | HDAC6 (0.54) | SMN1; SMN2ALDH1A1MEN1KMT2AHDAC6 | |
| SCHEMBL11377556 | 0.85 | HDAC6 (0.52) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL11389248 | 0.85 | YES1 (0.54) | SMN1; SMN2ALDH1A1MEN1KMT2AHDAC6 | |
| SCHEMBL11375809 | 0.85 | HDAC6 (0.59) | SMN1; SMN2ALDH1A1MEN1KMT2AHDAC6 | |
| SCHEMBL11376219 | 0.83 | HDAC6 (0.54) | SMN1; SMN2ALDH1A1HDAC6HDAC1HDAC8 | |
| SCHEMBL11382536 | 0.82 | HDAC6 (0.54) | RAB9ANPC1NPSR1ALDH1A1HDAC6 | |
| SCHEMBL11382798 | 0.81 | HDAC6 (0.51) | ALDH1A1HDAC6HDAC1HDAC8HDAC10 | |
| SCHEMBL11377629 | 0.80 | CYP19A1 (0.59) | RAB9ANPC1SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL6755431 | 0.78 | CYP19A1 (0.56) | SMN1; SMN2ALDH1A1MEN1KMT2AHDAC6 | |
| SCHEMBL11390324 | 0.78 | F2RL3 (0.55) | SMN1; SMN2HDAC6HDAC1HDAC8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4273782-A | FOR USE IN CARDIOVASCULAR DISORDERS AND COMPLICATIONS OF DIABETES | PFIZER INC. (US) | 1981-06-16 | — | — | US | disclosed |