Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11376219 | 0.92 | HDAC6 (0.54) | HDAC6HDAC1HDAC8HDAC10HDAC2 | |
| SCHEMBL11382536 | 0.90 | HDAC6 (0.54) | HDAC6HDAC1HDAC8HDAC10HDAC2 | |
| SCHEMBL11376099 | 0.89 | HDAC6 (0.54) | HDAC6HDAC1HDAC8HDAC10HDAC2 | |
| SCHEMBL11382798 | 0.87 | HDAC6 (0.51) | HDAC6HDAC1HDAC8HDAC10HDAC2 | |
| SCHEMBL11389248 | 0.87 | YES1 (0.54) | HDAC6HDAC1HDAC8HDAC10HDAC2 | |
| SCHEMBL11377556 | 0.87 | HDAC6 (0.52) | HDAC6HDAC1HDAC8HDAC10HDAC2 | |
| SCHEMBL6755431 | 0.85 | CYP19A1 (0.56) | HDAC6HDAC1HDAC8SMN1; SMN2CYP19A1 | |
| SCHEMBL11377635 | 0.85 | RAB9A (0.53) | HDAC6HDAC1HDAC8HDAC10HDAC2 | |
| SCHEMBL11377917 | 0.83 | LMNA (0.47) | HDAC6HDAC1HDAC8SMN1; SMN2HTT | |
| SCHEMBL11390324 | 0.83 | F2RL3 (0.55) | HDAC6HDAC1HDAC8HDAC10HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4273782-A | FOR USE IN CARDIOVASCULAR DISORDERS AND COMPLICATIONS OF DIABETES | PFIZER INC. (US) | 1981-06-16 | — | — | US | disclosed |