Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11380661 | 1.00 | MAPT (0.57) | MAPTMAPK1HPGDALDH1A1KDM4E | |
| SCHEMBL11382811 | 0.94 | MAPT (0.49) | MAPTMAPK1HPGDALDH1A1KDM4E | |
| SCHEMBL11382816 | 0.94 | MAPT (0.49) | MAPTMAPK1HPGDALDH1A1KDM4E | |
| SCHEMBL11372850 | 0.89 | MAPT (0.69) | MAPTMAPK1HPGDALDH1A1KDM4E | |
| SCHEMBL11372847 | 0.89 | MAPT (0.69) | MAPTMAPK1HPGDALDH1A1KDM4E | |
| SCHEMBL11373141 | 0.87 | MAPT (0.60) | MAPTMAPK1HPGDALDH1A1LMNA | |
| SCHEMBL11373142 | 0.87 | MAPT (0.60) | MAPTMAPK1HPGDALDH1A1LMNA | |
| SCHEMBL11375006 | 0.87 | OPRD1 (0.49) | MAPTALDH1A1LMNAOPRM1OPRD1 | |
| SCHEMBL11375005 | 0.87 | OPRD1 (0.49) | MAPTALDH1A1LMNAOPRM1OPRD1 | |
| SCHEMBL11376406 | 0.83 | MAPT (0.59) | MAPTMAPK1HPGDALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4267318-A | 1-(Diarylmethyl)-4-piperidinamine and derivatives thereof | G. D. SEARLE & CO. (US) | 1981-05-12 | — | — | US | disclosed |