Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.49 |
| ▸ | HTR3B | O95264 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4735759 | 0.82 | HRH4 (0.57) | HRH4HTR3AMAPT | |
| SCHEMBL11358141 | 0.76 | HRH4 (0.53) | HRH4KMT2AHTR3EHTR3BHTR3A | |
| SCHEMBL11343826 | 0.76 | NPSR1 (0.69) | HRH4KMT2AHTR3EHTR3BHTR3A | |
| SCHEMBL11341558 | 0.76 | HRH4 (0.50) | HRH4KMT2AHTR3EHTR3BHTR3A | |
| SCHEMBL11343044 | 0.76 | DRD2 (0.55) | KMT2AMAPTKDM4EHTT | |
| SCHEMBL4785362 | 0.74 | HRH4 (0.55) | HRH4HTR3A | |
| SCHEMBL11382668 | 0.73 | HRH4 (0.45) | HRH4KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL11349340 | 0.73 | HRH4 (0.49) | HRH4KMT2AHTR3EHTR3BHTR3A | |
| SCHEMBL11383726 | 0.72 | NPSR1 (0.50) | HRH4KMT2AHTR3EHTR3BHTR3A | |
| SCHEMBL20109603 | 0.71 | KMT2A (0.71) | HRH4KMT2AMAPTALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4282223-A | ANTIDEPRESSANTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-08-04 | — | — | US | disclosed |