SCHEMBL1138602

SCHEMBL1138602

CC(C)C[C@@]1(n2ccc(=O)[nH]c2=O)O[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 0.44

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SLC28A1 O00337 1/20 0.44
SLC28A2 O43868 1/20 0.44
SLC29A1 Q99808 1/20 0.44
SLC28A3 Q9HAS3 1/20 0.44
P2RY14 Q15391 3/20 0.38
P2RY6 Q15077 5/20 0.33
P2RY2 P41231 4/20 0.33
P2RY4 P51582 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2526251 0.91 SLC28A1 (0.43) SLC28A1SLC28A2SLC29A1SLC28A3P2RY14
SCHEMBL121731 0.87 SLC28A1 (0.47) SLC28A1SLC28A2SLC29A1SLC28A3P2RY14
SCHEMBL8941498 0.87 SLC28A1 (0.49) SLC28A1SLC28A2SLC29A1SLC28A3P2RY14
SCHEMBL1532519 0.87 SLC28A1 (0.49) SLC28A1SLC28A2SLC29A1SLC28A3P2RY14
SCHEMBL28250490 0.85 SLC28A1 (0.48) SLC28A1SLC28A2SLC29A1SLC28A3P2RY14
SCHEMBL28358233 0.85 SLC28A1 (0.42) SLC28A1SLC28A2SLC29A1SLC28A3P2RY14
SCHEMBL3827548 0.85 SLC28A1 (0.45) SLC28A1SLC28A2SLC29A1SLC28A3P2RY14
SCHEMBL6879975 0.85 SLC28A1 (0.45) SLC28A1SLC28A2SLC29A1SLC28A3P2RY14
SCHEMBL6389231 0.84 SLC28A1 (0.47) SLC28A1SLC28A2SLC29A1SLC28A3P2RY14
SCHEMBL9644061 0.84 SLC28A1 (0.47) SLC28A1SLC28A2SLC29A1SLC28A3P2RY14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0948256-A4 INDUCTION OF VIRAL MUTATION BY INCORPORATION OF MISCODING RIBONUCLEOSIDE ANALOGS INTO VIRAL RNA UNIV WASHINGTON (US) 2007-10-24 EP claimed
US-6887707-B2 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA UNIVERSITY OF WASHINGTON (US) 2005-05-03 US claimed
US-20030119764-A1 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2003-06-26 US claimed
EP-0948256-A1 INDUCTION OF VIRAL MUTATION BY INCORPORATION OF MISCODING RIBONUCLEOSIDE ANALOGS INTO VIRAL RNA THE UNIVERSITY OF WASHINGTON (US) 1999-10-13 EP claimed
WO-1998018324-A1 INDUCTION OF VIRAL MUTATION BY INCORPORATION OF MISCODING RIBONUCLEOSIDE ANALOGS INTO VIRAL RNA THE UNIVERSITY OF WASHINGTON (US) 1998-05-07 WO claimed
US-20240052357-A1 AUTONOMOUS INDUCIBLE DIRECTED EVOLUTION OF COMPLEX PATHWAYS NORTH CAROLINA STATE UNIVERSITY 2024-02-15 US disclosed
EP-1576154-B8 IN VIVO AFFINITY MATURATION SCHEME ANAPTYSBIO INC (US) 2011-04-13 EP disclosed
EP-1576154-B1 IN VIVO AFFINITY MATURATION SCHEME QUINTAIN CONSULTING PTY LTD (AU) 2011-02-23 EP disclosed
US-20090311710-A1 MUTAGENESIS METHODS USING RIBAVIRIN AND/OR RNA REPLICASES COIA GREGORY 2009-12-17 US disclosed
WO-2009043096-A1 IMPROVED METHOD FOR MUTAGENESIS ARANA THERAPEUTICS (VIC) PTY LTD (AU) 2009-04-09 WO disclosed
EP-0948256-A4 INDUCTION OF VIRAL MUTATION BY INCORPORATION OF MISCODING RIBONUCLEOSIDE ANALOGS INTO VIRAL RNA UNIV WASHINGTON (US) 2007-10-24 EP disclosed
EP-1558745-A4 MUTAGENESIS METHODS USING RIBAVIRIN AND/OR RNA REPLICASES EVOGENIX PTY LTD (AU) 2006-08-30 EP disclosed
EP-1558745-A1 MUTAGENESIS METHODS USING RIBAVIRIN AND/OR RNA REPLICASES Evogenix Pty Ltd (AU) 2005-08-03 EP disclosed
US-6887707-B2 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA UNIVERSITY OF WASHINGTON (US) 2005-05-03 US disclosed
WO-2004055182-A1 IN VIVO AFFINITY MATURATION SCHEME DIATECH PTY LTD (AU) 2004-07-01 WO disclosed
WO-2004039995-A1 MUTAGENESIS METHODS USING RIBAVIRIN AND/OR RNA REPLICASES EVOGENIX PTY LTD (AU) 2004-05-13 WO disclosed
US-20030148267-A1 Screening assay for hepatitis C virus antiviral agents NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2003-08-07 US disclosed
US-20030119764-A1 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2003-06-26 US disclosed
EP-0948256-A1 INDUCTION OF VIRAL MUTATION BY INCORPORATION OF MISCODING RIBONUCLEOSIDE ANALOGS INTO VIRAL RNA THE UNIVERSITY OF WASHINGTON (US) 1999-10-13 EP disclosed
WO-1998018324-A1 INDUCTION OF VIRAL MUTATION BY INCORPORATION OF MISCODING RIBONUCLEOSIDE ANALOGS INTO VIRAL RNA THE UNIVERSITY OF WASHINGTON (US) 1998-05-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030119764-A1 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA SAMHD1, BCDIN3D, DCTD SLC28A1 891/4885SLC28A2 952/4885SLC29A1 304/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.