Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.73 |
| ▸ | RAB9A | P51151 | 8/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | C1R | P00736 | 6/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11379454 | 0.88 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL19899736 | 0.83 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL11378058 | 0.82 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL27596616 | 0.82 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL3949035 | 0.79 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL2433790 | 0.79 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL11385445 | 0.78 | NPC1 (0.80) | NPC1RAB9ASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL27578613 | 0.78 | RAB9A (0.57) | NPC1RAB9ASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL14591725 | 0.78 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL27578582 | 0.77 | RAB9A (0.69) | NPC1RAB9ASMN1; SMN2GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4275210-A | IMMUNOSUPPRESSIVE AGENTS, ANTIFERTILITY AGENTS, PROPHYLAXIS OF MAREK'S DISEASE IN CHICKENS AND HERBICIDES | ELI LILLY AND COMPANY (US) | 1981-06-23 | — | — | US | disclosed |
| US-4088770-A | ANTIFERTILITY, HERBICIDES | ELI LILLY AND COMPANY (US) | 1978-05-09 | — | — | US | disclosed |