Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12317726 | 0.88 | GAA (0.52) | TSHRGAAMAPTLMNATDP1 | |
| SCHEMBL18158251 | 0.88 | POLB (0.74) | TSHRGAAMAPTPOLBMEN1 | |
| SCHEMBL381076 | 0.88 | POLB (0.53) | TSHRGAAMAPTLMNATDP1 | |
| SCHEMBL12317935 | 0.87 | TSHR (0.59) | TSHRGAAMAPTLMNATDP1 | |
| SCHEMBL3171431 | 0.86 | POLB (0.51) | TSHRGAAMAPTLMNATDP1 | |
| SCHEMBL9829525 | 0.85 | MAPT (0.53) | GAAMAPTLMNATDP1POLB | |
| SCHEMBL13444627 | 0.85 | LMNA (0.61) | TSHRGAAMAPTLMNAPOLB | |
| SCHEMBL7101006 | 0.85 | MAPT (0.60) | TSHRGAAMAPTLMNAPOLB | |
| SCHEMBL9830217 | 0.84 | MAPT (0.55) | TSHRGAAMAPTLMNATDP1 | |
| SCHEMBL7338663 | 0.84 | TSHR (0.65) | TSHRGAAMAPTLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4281018-A | HYPOLIPIDEMIC AND ANTIATHEROSCLEROTIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1981-07-28 | — | — | US | disclosed |
| US-4230628-A | HYPOLIPIDEMIC AGENTS, ANTIATHEROSCLEROSIS | AMERICAN CYANAMID COMPANY (US) | 1980-10-28 | — | — | US | disclosed |