Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11400133 | 0.91 | ALDH1A1 (0.45) | THRBLMNAKMT2APDE4BALDH1A1 | |
| SCHEMBL11397127 | 0.91 | PDE4B (0.49) | THRBLMNAKMT2APDE4BALDH1A1 | |
| SCHEMBL11400866 | 0.87 | KMT2A (0.56) | THRBLMNAKMT2APDE4BALDH1A1 | |
| SCHEMBL11149657 | 0.84 | KMT2A (0.58) | THRBLMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL11397250 | 0.83 | PDE3B (0.48) | THRBLMNAKMT2APDE4BALDH1A1 | |
| SCHEMBL11391393 | 0.82 | PDE4B (0.46) | THRBLMNAKMT2APDE4BALDH1A1 | |
| SCHEMBL11238845 | 0.82 | KMT2A (0.45) | THRBLMNAKMT2APDE4BALDH1A1 | |
| SCHEMBL21144549 | 0.81 | PDE4B (0.47) | THRBLMNAKMT2APDE4BALDH1A1 | |
| SCHEMBL17504206 | 0.80 | TP53 (0.54) | LMNAKMT2AALDH1A1MEN1TP53 | |
| SCHEMBL11401967 | 0.78 | TP53 (0.50) | THRBLMNAKMT2APDE4BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0010156-A1 | 6-Arylpyridazine-3-ones, pharmaceutical compositions containing them and process for their preparation | MERCK PATENT GmbH (DE) | 1980-04-30 | — | — | EP | claimed |
| US-4289774-A | Lipid lowering and anti-thrombotic 6-arylpyridazin-3-ones and a process for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-09-15 | — | — | US | disclosed |
| EP-0010156-A1 | 6-Arylpyridazine-3-ones, pharmaceutical compositions containing them and process for their preparation | MERCK PATENT GmbH (DE) | 1980-04-30 | — | — | EP | disclosed |