Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3839136 | 0.89 | KDM4E (0.60) | KDM4EHTTTSHRHSD17B10MEN1 | |
| SCHEMBL11399679 | 0.86 | KDM4E (0.58) | KDM4EHTTTSHRHSD17B10MEN1 | |
| SCHEMBL11397982 | 0.78 | ALDH1A1 (0.45) | KDM4EHSD17B10KMT2A | |
| SCHEMBL11096921 | 0.76 | MEN1 (0.59) | KDM4EHTTTSHRHSD17B10MEN1 | |
| SCHEMBL11245497 | 0.75 | MAPT (0.50) | KDM4EHTTTSHRHSD17B10MEN1 | |
| SCHEMBL3864325 | 0.75 | KDM4E (0.52) | KDM4EHTTTSHRHSD17B10MEN1 | |
| SCHEMBL7299166 | 0.74 | ADORA1 (0.77) | KDM4EHTTTSHR | |
| SCHEMBL16117950 | 0.74 | KDM4E (0.69) | KDM4EHTTTSHRHSD17B10MEN1 | |
| SCHEMBL7679338 | 0.73 | KDM4E (0.57) | KDM4EHTTTSHRHSD17B10MEN1 | |
| SCHEMBL3843267 | 0.73 | MEN1 (0.60) | KDM4EHTTTSHRHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4289774-A | Lipid lowering and anti-thrombotic 6-arylpyridazin-3-ones and a process for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-09-15 | — | — | US | disclosed |
| EP-0010156-A1 | 6-Arylpyridazine-3-ones, pharmaceutical compositions containing them and process for their preparation | MERCK PATENT GmbH (DE) | 1980-04-30 | — | — | EP | disclosed |