Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GABRP | O00591 | 1/20 | 0.45 |
| ▸ | GABRD | O14764 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1810634 | 0.88 | NAMPT (0.45) | NPC1RAB9ANAMPTP4HTMKDM4E | |
| SCHEMBL20379645 | 0.85 | MAPT (0.54) | NPC1RAB9AHPGDCRHBPCRHR2 | |
| SCHEMBL30112066 | 0.83 | CYP1A2 (0.47) | NPC1RAB9AHPGDP4HTMKDM4E | |
| SCHEMBL19555950 | 0.83 | CYP1A2 (0.47) | NPC1RAB9AHPGDP4HTMKDM4E | |
| SCHEMBL29031095 | 0.82 | SMN1; SMN2 (0.67) | NPC1RAB9AP4HTMSMN1; SMN2HTT | |
| SCHEMBL28844082 | 0.82 | KDM4E (0.49) | NPC1RAB9AHPGDCRHBPCRHR2 | |
| SCHEMBL7896726 | 0.81 | KCNQ3 (0.54) | NPC1RAB9AHPGDCRHBPCRHR2 | |
| SCHEMBL9673301 | 0.81 | SMN1; SMN2 (0.54) | NPC1RAB9AHPGDCRHBPCRHR2 | |
| SCHEMBL29031128 | 0.81 | SMN1; SMN2 (0.47) | NPC1RAB9AHPGDP4HTMKDM4E | |
| SCHEMBL28543158 | 0.79 | SMN1; SMN2 (0.53) | NPC1RAB9AHPGDKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4273779-A | Treating hypertension with substituted-5-amino-2-pyridinecarboxylic acids | CIBA-GEIGY CORPORATION (US) | 1981-06-16 | — | — | US | disclosed |