SCHEMBL11409473

SCHEMBL11409473

COc1ccc(-c2noc3cc(-c4ccccc4)n(C)c(=O)c23)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 3/20 1.00
NPC1 O15118 6/20 0.81
RAB9A P51151 5/20 0.81
CASP3 P42574 1/20 0.81
SENP8 Q96LD8 1/20 0.81
SENP7 Q9BQF6 1/20 0.81
SENP6 Q9GZR1 1/20 0.81
MITF O75030 1/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2488636 1.00 NR4A2 (1.00) NR4A2NPC1RAB9ACASP3SENP8
SCHEMBL2485014 0.91 NR4A2 (0.83) NR4A2NPC1RAB9ACASP3SENP8
SCHEMBL11615525 0.91 NR4A2 (0.83) NR4A2NPC1RAB9ACASP3SENP8
SCHEMBL5537019 0.91 NPC1 (0.85) NR4A2NPC1RAB9ACASP3SENP8
SCHEMBL5532304 0.90 NPC1 (0.95) NR4A2NPC1RAB9ACASP3SENP8
SCHEMBL3663640 0.90 NPC1 (1.00) NR4A2NPC1RAB9ACASP3SENP8
SCHEMBL6069177 0.90 NPC1 (1.00) NR4A2NPC1RAB9ACASP3SENP8
SCHEMBL3014586 0.90 NR4A2 (0.81) NR4A2NPC1RAB9ACASP3SENP8
SCHEMBL6068962 0.89 NR4A2 (0.80) NR4A2NPC1RAB9ACASP3SENP8
Hydrochloric Acid SCHEMBL20836388 0.89 NR4A2 (0.80) NR4A2NPC1RAB9ACASP3SENP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4238616-A TRANQUILIZERS SANDOZ, INC. (US) 1980-12-09 US disclosed
US-4208532-A TRANQUILIZER AND SEDATIVE INTERMEDIATES SANDOZ, INC. (US) 1980-06-17 US disclosed
US-4158735-A TRANQUILIZERS, SLEEP INDUCERS SANDOZ, INC. (US) 1979-06-19 US disclosed
US-4103013-A TRANQUILIZERS, SLEEP INDUCERS SANDOZ, INC. (US) 1978-07-25 US disclosed