Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 1.00 |
| ▸ | RAB9A | P51151 | 5/20 | 1.00 |
| ▸ | MITF | O75030 | 1/20 | 1.00 |
| ▸ | CASP3 | P42574 | 1/20 | 0.88 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.88 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.88 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.88 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.78 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2482092 | 1.00 | NPC1 (1.00) | NPC1RAB9AMITFCASP3SENP8 | |
| SCHEMBL17965446 | 0.94 | NPC1 (0.89) | NPC1RAB9AMITFCASP3SENP8 | |
| SCHEMBL5532304 | 0.94 | NPC1 (0.95) | NPC1RAB9AMITFCASP3SENP8 | |
| SCHEMBL3663640 | 0.94 | NPC1 (1.00) | NPC1RAB9AMITFCASP3SENP8 | |
| SCHEMBL11420874 | 0.89 | NPC1 (0.85) | NPC1RAB9AMITFCASP3SENP8 | |
| SCHEMBL11617747 | 0.89 | NPC1 (0.80) | NPC1RAB9AMITFCASP3SENP8 | |
| SCHEMBL11406007 | 0.89 | NPC1 (0.85) | NPC1RAB9AMITFCASP3SENP8 | |
| SCHEMBL11618338 | 0.89 | NPC1 (0.81) | NPC1RAB9AMITFCASP3SENP8 | |
| SCHEMBL11420574 | 0.89 | NPC1 (0.85) | NPC1RAB9AMITFCASP3SENP8 | |
| SCHEMBL11613192 | 0.89 | NPC1 (0.80) | NPC1RAB9AMITFCASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4238616-A | TRANQUILIZERS | SANDOZ, INC. (US) | 1980-12-09 | — | — | US | disclosed |
| US-4208532-A | TRANQUILIZER AND SEDATIVE INTERMEDIATES | SANDOZ, INC. (US) | 1980-06-17 | — | — | US | disclosed |
| US-4158735-A | TRANQUILIZERS, SLEEP INDUCERS | SANDOZ, INC. (US) | 1979-06-19 | — | — | US | disclosed |
| US-4154928-A | Substituted isoxazolo compounds | SANDOZ, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4113727-A | Process for the preparation of substituted isoxazolo[4,5-c]pyridin-4-(5H)-ones | SANDOZ, INC. (US) | 1978-09-12 | — | — | US | disclosed |
| US-4103013-A | TRANQUILIZERS, SLEEP INDUCERS | SANDOZ, INC. (US) | 1978-07-25 | — | — | US | disclosed |