Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | DHODH | Q02127 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | LIG1 | P18858 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11411247 | 1.00 | MEN1 (0.46) | MEN1KMT2ADHODHCA12CA2 | |
| SCHEMBL11422778 | 0.85 | AKR1C3 (0.45) | MEN1KMT2ADHODHCA12CA2 | |
| SCHEMBL11422776 | 0.85 | AKR1C3 (0.45) | MEN1KMT2ADHODHCA12CA2 | |
| SCHEMBL5479008 | 0.85 | CA2 (0.46) | MEN1KMT2ACA12CA2CA9 | |
| SCHEMBL5479012 | 0.85 | CA2 (0.46) | MEN1KMT2ACA12CA2CA9 | |
| SCHEMBL5084597 | 0.84 | MAPT (0.50) | MEN1KMT2ADHODHCA12CA2 | |
| SCHEMBL5084594 | 0.84 | MAPT (0.50) | MEN1KMT2ADHODHCA12CA2 | |
| SCHEMBL5078669 | 0.82 | MAPT (0.49) | MEN1KMT2ADHODHCA12CA2 | |
| SCHEMBL5078670 | 0.82 | MAPT (0.49) | MEN1KMT2ADHODHCA12CA2 | |
| SCHEMBL14337533 | 0.80 | CA2 (0.55) | MEN1KMT2ADHODHCA12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4235929-A | TOPICAL ADMINISTRATION OF ANTIINFLAMMATORY AGENT | WILLIAM H. RORER, INC. (US) | 1980-11-25 | — | — | US | disclosed |
| US-4198349-A | ANTIINFLAMMATORY, TOPICAL | WILLIAM H. RORER, INC. (US) | 1980-04-15 | — | — | US | disclosed |
| US-4176198-A | ANTIINFLAMMATORY AGENTS | WILLIAM H. RORER, INC. (US) | 1979-11-27 | — | — | US | disclosed |