Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.57 |
| ▸ | TRPM8 | Q7Z2W7 | 7/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6872884 | 0.88 | EPHX1 (0.57) | EPHX1TRPM8TRPA1TRPV1CYP19A1 | |
| SCHEMBL6871882 | 0.85 | EPHX1 (0.54) | EPHX1TRPM8TRPA1TRPV1 | |
| SCHEMBL6872036 | 0.84 | EPHX1 (0.60) | EPHX1TRPM8TRPA1TRPV1CYP19A1 | |
| SCHEMBL6869088 | 0.82 | EPHX1 (0.51) | EPHX1TRPM8TRPA1 | |
| SCHEMBL6871372 | 0.80 | EPHX1 (0.64) | EPHX1TRPM8TRPA1TRPV1ALDH1A1 | |
| SCHEMBL6868917 | 0.80 | EPHX1 (0.51) | EPHX1TRPM8TRPA1 | |
| Ethylene Glycol SCHEMBL2355787 | 0.79 | EPHX1 (0.62) | EPHX1TRPM8TRPA1TRPV1CYP19A1 | |
| SCHEMBL2160803 | 0.78 | EPHX1 (0.53) | EPHX1TRPM8TRPA1TRPV1 | |
| SCHEMBL20226808 | 0.78 | EPHX1 (0.60) | EPHX1TRPM8TRPA1TRPV1CYP19A1 | |
| SCHEMBL6870235 | 0.77 | EPHX1 (0.49) | EPHX1TRPM8TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4226988-A | SKIN COOLANTS | WILKINSON SWORD LIMITED (GB) | 1980-10-07 | — | — | US | disclosed |
| US-4193936-A | N-substituted paramenthane carboxamides | WILKINSON SWORD LIMITED (GB) | 1980-03-18 | — | — | US | disclosed |
| US-4178459-A | N-Substituted paramenthane carboxamides | WILKINSON SWORD LIMITED (GB) | 1979-12-11 | — | — | US | disclosed |
| US-4150052-A | PHYSIOLOGICAL COOLING EFFECT ON SKIN | WILKINSON SWORD LIMITED (GB) | 1979-04-17 | — | — | US | disclosed |
| US-4136163-A | P-MENTHANE CARBOXAMIDES HAVING A PHYSIOLOGICAL COOLING EFFECT | WILKINSON SWORD LIMITED (GB) | 1979-01-23 | — | — | US | disclosed |