Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.53 |
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6872036 | 0.90 | EPHX1 (0.60) | EPHX1TRPM8TRPA1OPRM1TRPV1 | |
| SCHEMBL6868917 | 0.82 | EPHX1 (0.51) | EPHX1TRPM8TRPA1OPRM1 | |
| SCHEMBL6872884 | 0.81 | EPHX1 (0.57) | EPHX1TRPM8TRPA1OPRM1TRPV1 | |
| SCHEMBL6870235 | 0.80 | EPHX1 (0.49) | EPHX1TRPM8TRPA1OPRM1 | |
| SCHEMBL28483191 | 0.79 | EPHX1 (0.51) | EPHX1TRPM8TRPA1TRPV1 | |
| SCHEMBL6871882 | 0.78 | EPHX1 (0.54) | EPHX1TRPM8TRPA1OPRM1TRPV1 | |
| SCHEMBL11412976 | 0.78 | EPHX1 (0.57) | EPHX1TRPM8TRPA1TRPV1 | |
| SCHEMBL6871372 | 0.77 | EPHX1 (0.64) | EPHX1TRPM8TRPA1TRPV1 | |
| SCHEMBL6869088 | 0.76 | EPHX1 (0.51) | EPHX1TRPM8TRPA1OPRM1 | |
| SCHEMBL3392793 | 0.75 | EPHX1 (0.47) | EPHX1TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032003-B | Cooling and flavor enhancing compositions | 弗门尼舍有限公司 | 2023-03-17 | — | — | CN | claimed |
| US-8377422-B2 | Carboxamide derivatives having cooling properties | GIVAUDAN S.A. (CH) | 2013-02-19 | — | — | US | claimed |
| US-20110182833-A1 | Carboxamide Derivatives Having Cooling Properties | GIVAUDAN SA (CH) | 2011-07-28 | — | — | US | claimed |
| US-20100297038-A1 | Benzimidazole Derivatives And Their Use As Cooling Agents | GIVAUDAN S.A. (CH) | 2010-11-25 | — | — | US | claimed |
| EP-2250154-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS COOLING AGENTS | Givaudan SA (CH) | 2010-11-17 | — | — | EP | claimed |
| EP-2229352-A2 | CARBOXAMIDE DERIVATIVES HAVING COOLING PROPERTIES | Givaudan SA (CH) | 2010-09-22 | — | — | EP | claimed |
| WO-2009089641-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS COOLING AGENTS | GIVAUDAN SA (CH) | 2009-07-23 | — | — | WO | claimed |
| WO-2009070910-A2 | CARBOXAMIDE DERIVATIEVES HAVING COOLING PROPERTIES | GIVAUDAN SA (CH) | 2009-06-11 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100297038-A1 | Benzimidazole Derivatives And Their Use As Cooling Agents | OR10J3, H1-3, ORC3 | EPHX1 2518/4885TRPM8 2049/4885TRPA1 1135/4885 |
| US-20110182833-A1 | Carboxamide Derivatives Having Cooling Properties | CPS1, NQO2, NDUFA2 | EPHX1 3112/4885TRPM8 376/4885TRPA1 267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.