Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 9/20 | 0.69 |
| ▸ | PGR | P06401 | 8/20 | 0.69 |
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.69 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.69 |
| ▸ | CNR1 | P21554 | 3/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.64 |
| ▸ | USP2 | O75604 | 7/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | MLNR | O43193 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.64 |
| ▸ | PPARG | P37231 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11418175 | 1.00 | NR3C1 (0.69) | NR3C1PGRLMNAHIF1ANR1I2 | |
| SCHEMBL11586775 | 0.93 | NR3C1 (0.63) | NR3C1PGRLMNAHIF1ANR1I2 | |
| SCHEMBL11586778 | 0.93 | NR3C1 (0.63) | NR3C1PGRLMNAHIF1ANR1I2 | |
| SCHEMBL11323834 | 0.93 | NR3C1 (0.71) | NR3C1PGRLMNAHIF1ANR1I2 | |
| SCHEMBL11323839 | 0.93 | NR3C1 (0.71) | NR3C1PGRLMNAHIF1ANR1I2 | |
| SCHEMBL24581296 | 0.93 | NR3C1 (0.71) | NR3C1PGRLMNAHIF1ANR1I2 | |
| SCHEMBL24581680 | 0.93 | NR3C1 (0.71) | NR3C1PGRLMNAHIF1ANR1I2 | |
| SCHEMBL11586140 | 0.93 | NR3C1 (0.71) | NR3C1PGRLMNAHIF1ANR1I2 | |
| SCHEMBL11415042 | 0.92 | NR3C1 (0.69) | NR3C1PGRLMNAHIF1ANR1I2 | |
| SCHEMBL11421850 | 0.92 | NR3C1 (0.69) | NR3C1PGRLMNAHIF1ANR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4201778-A | 6-Acyloxy-1,4,6-pregnatrienes, their use as anti-inflammatory agents, methods for their manufacture, and 6-oxo-1,4-pregnadiene intermediates | SCHERING CORPORATION (US) | 1980-05-06 | — | — | US | disclosed |
| US-4124707-A | 7α-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor | SCHERING CORPORATION (US) | 1978-11-07 | — | — | US | disclosed |
| US-4021459-A | Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy 20-keto-pregnenes | SCHERING CORPORATION (US) | 1977-05-03 | — | — | US | disclosed |
| US-3992422-A | Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes | SCHERING CORPORATION (US) | 1976-11-16 | — | — | US | disclosed |