Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 9/20 | 0.80 |
| ▸ | PGR | P06401 | 5/20 | 0.80 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.80 |
| ▸ | MAPT | P10636 | 2/20 | 0.80 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.80 |
| ▸ | DRD2 | P14416 | 1/20 | 0.80 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.79 |
| ▸ | USP2 | O75604 | 5/20 | 0.79 |
| ▸ | LMNA | P02545 | 2/20 | 0.79 |
| ▸ | MLNR | O43193 | 1/20 | 0.79 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.79 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.79 |
| ▸ | PPARG | P37231 | 1/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.79 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.79 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.79 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11416504 | 0.93 | NR3C1 (0.83) | NR3C1PGRNR1I2MAPTADORA3 | |
| SCHEMBL7204749 | 0.92 | NR3C1 (0.68) | NR3C1PGRNR1I2MAPTADORA3 | |
| SCHEMBL7203678 | 0.91 | NR3C1 (0.66) | NR3C1PGRNR1I2MAPTADORA3 | |
| SCHEMBL8502507 | 0.91 | NR3C1 (0.67) | NR3C1PGRNR1I2MAPTADORA3 | |
| SCHEMBL8504838 | 0.91 | NR3C1 (0.67) | NR3C1PGRNR1I2MAPTADORA3 | |
| SCHEMBL11583449 | 0.90 | NR3C1 (0.86) | NR3C1PGRNR1I2MAPTADORA3 | |
| SCHEMBL11583451 | 0.90 | NR3C1 (0.86) | NR3C1PGRNR1I2MAPTADORA3 | |
| SCHEMBL9835214 | 0.90 | NR3C1 (0.83) | NR3C1PGRNR1I2MAPTADORA3 | |
| SCHEMBL11845108 | 0.90 | NR3C1 (0.83) | NR3C1PGRNR1I2MAPTADORA3 | |
| SCHEMBL11842212 | 0.90 | NR3C1 (0.83) | NR3C1PGRNR1I2MAPTADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4201778-A | 6-Acyloxy-1,4,6-pregnatrienes, their use as anti-inflammatory agents, methods for their manufacture, and 6-oxo-1,4-pregnadiene intermediates | SCHERING CORPORATION (US) | 1980-05-06 | — | — | US | disclosed |
| EP-0001864-A1 | Novel 6-oxygenated-3,20-dioxo-pregnane derivatives, process for the preparation thereof, and pharmaceutical compositions containing them | Technobiotic Ltd. (CH) | 1979-05-16 | — | — | EP | disclosed |
| US-4124707-A | 7α-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor | SCHERING CORPORATION (US) | 1978-11-07 | — | — | US | disclosed |