Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.58 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | STAT1 | P42224 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11425132 | 0.93 | PTGS1 (0.63) | PTGS1AKR1C3AKR1C2KDM4ELCK | |
| SCHEMBL11439398 | 0.82 | LMNA (0.57) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL11422665 | 0.82 | GAA (0.51) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL11437909 | 0.82 | MAPT (0.50) | KDM4EALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL11430207 | 0.80 | AKR1B1 (0.51) | KDM4ELCKALDH1A1HPGDHSD17B10 | |
| SCHEMBL11423124 | 0.80 | NPC1 (0.49) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL11424295 | 0.79 | TTR (0.49) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL11425177 | 0.79 | TTR (0.51) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL31716048 | 0.79 | GAA (0.44) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL11435244 | 0.79 | GAA (0.44) | KDM4EALDH1A1HPGDHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4222944-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-09-16 | — | — | US | disclosed |
| US-4192809-A | USED A ANTIINFLAMMATORY, ANALGESIC, AND ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-03-11 | — | — | US | disclosed |
| US-4097497-A | ANTIINFLAMMATORY, ANALGESICS, ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1978-06-27 | — | — | US | disclosed |
| US-4022805-A | ANTIINFLAMMATORY, ANALGESIC, ANTIRHEUMATIC | HOFFMANN-LA ROCHE INC. (US) | 1977-05-10 | — | — | US | disclosed |