Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6299755 | 0.82 | TAAR1 (0.51) | CYP2D6MEN1KMT2ATSHRTAAR1 | |
| SCHEMBL6299922 | 0.82 | TAAR1 (0.51) | CYP2D6MEN1KMT2ATSHRTAAR1 | |
| SCHEMBL11433350 | 0.80 | AOC3 (0.49) | ADRA2AADRA2BADRA2CCYP2D6AOC3 | |
| SCHEMBL11296792 | 0.78 | TAAR1 (0.42) | MEN1KMT2ATAAR1HTR1A | |
| SCHEMBL11289983 | 0.77 | TAAR1 (0.44) | TAAR1HTR1A | |
| SCHEMBL3528465 | 0.75 | TAAR1 (0.39) | MEN1KMT2ATAAR1 | |
| SCHEMBL3529536 | 0.75 | TAAR1 (0.39) | ADRA2AADRA2BADRA2CTAAR1 | |
| SCHEMBL3913688 | 0.75 | TAAR1 (0.39) | MEN1KMT2ATAAR1 | |
| SCHEMBL8488446 | 0.75 | TAAR1 (0.37) | ADRA2AADRA2BADRA2CCYP2D6CYP1A2 | |
| SCHEMBL11566236 | 0.74 | ADRA2A (0.54) | ADRA2AADRA2BADRA2CCYP2D6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0013786-A1 | Imidazole derivatives, pharmaceutical compositions containing them and their preparation | SYNTEX (U.S.A.) INC. (US) | 1980-08-06 | — | — | EP | disclosed |
| EP-0001926-A1 | 1-(Naphthylethyl)imidazole derivatives, their preparation, and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1979-05-16 | — | — | EP | disclosed |