Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | MPL | P40238 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 2/20 | 0.37 |
| ▸ | KLK1 | P06870 | 2/20 | 0.37 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.36 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.36 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | DDX3X | O00571 | 1/20 | 0.35 |
| ▸ | ATIC | P31939 | 1/20 | 0.35 |
| ▸ | SUMO2 | P61956 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11439444 | 0.91 | TTR (0.43) | TTRMPLAURKAAURKBPLG | |
| SCHEMBL11439417 | 0.89 | MPL (0.46) | MPLHSD17B10KDM4EDDX3XSUMO2 | |
| SCHEMBL11438683 | 0.87 | AURKA (0.41) | TTRMPLAURKAAURKBPLG | |
| Acetic Acid SCHEMBL11425024 | 0.86 | MPL (0.43) | MPLHSD17B10KDM4ESUMO2SUMO1 | |
| SCHEMBL11425723 | 0.85 | TTR (0.43) | TTRAURKAAURKBPLGKLK1 | |
| SCHEMBL11433572 | 0.84 | MPL (0.41) | MPLPLGKLK1KLK6HSD17B10 | |
| SCHEMBL11433116 | 0.84 | GRM5 (0.39) | PLGKLK1KLK6GRM5HKDC1 | |
| SCHEMBL11421989 | 0.83 | KCNMA1 (0.47) | ALDH1A1KDM4EMEN1KMT2AKCNMA1 | |
| SCHEMBL11431273 | 0.83 | SNCA (0.43) | TTRMPLAURKAAURKBPLG | |
| SCHEMBL11440791 | 0.83 | PLG (0.45) | TTRAURKAAURKBPLGKLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4216165-A | Amine precursors to ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |