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KCNMA1

Calcium-activated potassium channel subunit alpha-1 · Q12791 · KCNMA1 on Sugi Atlas →

27,337 patent compounds predicted against KCNMA1, 19,211 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL329958 SCHEMBL329958 0.77 14/20
SCHEMBL247350 SCHEMBL247350 0.60 11/20
SCHEMBL586094 SCHEMBL586094 0.47 10/20
SCHEMBL330467 SCHEMBL330467 0.57 8/20
SCHEMBL330732 SCHEMBL330732 0.52 8/20
Niclosamide Niclosamide (SCHEMBL67182) 0.73 7/20
SCHEMBL330249 SCHEMBL330249 0.63 6/20
SCHEMBL330387 SCHEMBL330387 0.81 5/20
SCHEMBL330431 SCHEMBL330431 0.72 5/20
SCHEMBL330019 SCHEMBL330019 0.64 5/20
SCHEMBL330588 SCHEMBL330588 0.62 5/20
SCHEMBL391334 SCHEMBL391334 0.51 5/20
SCHEMBL330373 SCHEMBL330373 0.50 5/20
SCHEMBL666185 SCHEMBL666185 0.49 5/20
Dinitro Cresol Dinitro Cresol (SCHEMBL622343) 0.47 5/20
SCHEMBL96175 SCHEMBL96175 0.71 4/20
SCHEMBL345091 SCHEMBL345091 0.67 4/20
SCHEMBL502853 SCHEMBL502853 0.67 4/20
SCHEMBL345233 SCHEMBL345233 0.65 4/20
SCHEMBL343717 SCHEMBL343717 0.64 4/20

Clinical trials — most relevant to KCNMA1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Multimodal Versus Opioid aNalgesia in carDiAc Surgery PHASE4COMPLETED
Role of Eplerenone in Reducing Recurrence of Atrial Fibrillation in Patient With Structural Heart Disease PHASE4NOT_YET_RECRUITING
Levosimendan in Acute Decompensated Heart Failure PHASE2/PHASE3NOT_YET_RECRUITING
4-Aminopyridine in Episodic Ataxia Type 2 PHASE2WITHDRAWN
Sandostatine® LP and Hyperinsulinism PHASE2COMPLETED
A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy PHASE1/PHASE2RECRUITING
Mutation-specific Therapy for the Long QT Syndrome PHASE2COMPLETED
Safety and Efficacy of MEM 1003 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease PHASE2COMPLETED
Safety, Blood Levels and Effects of AUT00201 in Patients With MEAK PHASE1COMPLETED
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients. nanUNKNOWN
Gene Study for Infantile Onset Diabetes nanUNKNOWN
The Physiological Effects of Human Ether-a-go-go-Related Gene (hERG)Blockade on Metabolism nanCOMPLETED
Targeting Potassium Channels to Reprogram Glioblastoma Microenvironment: in Vitro and in Vivo Studies nanUNKNOWN
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain. nanUNKNOWN
Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation nanUNKNOWN
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives nanUNKNOWN
Characteristics of Episodic Ataxia Syndrome nanCOMPLETED
A Cohort Study on the Prognosis of Neonatal KCNQ2 Gene-associated Epileptic Encephalopathy nanUNKNOWN
Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome nanRECRUITING
Genetic Determinants of Sudden Cardiac Death nanCOMPLETED
Role of Nitric Oxide in Diabetic Patients With Erectile Dysfunction nanCOMPLETED
The Effects of the Anesthetic Drug Propofol on the Way the Heart Recovers Between Beats nanCOMPLETED
Qatar Cardiovascular Biorepository of AF Patients nanUNKNOWN
The Effects of the Anti Nausea Drugs Droperidol and Ondansetron on the Way the Heart Recovers Between Beats nanCOMPLETED
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services nanUNKNOWN
Characteristics of Andersen-Tawil Syndrome nanCOMPLETED
MRI-phenotyping of Patients With Pathogenic Anoctamin 5 Variants nanRECRUITING
Metabolism of Patients With Genetically Caused Cardiac Arrhythmia nanUNKNOWN
Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA) nanUNKNOWN
The Prevalence of RYR1-related Disease nanNOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a KCNMA1 binder may also engage these)

ProteinNameSimilarity
Q9BG98 — 1.000 Q9BG98 →
Q28204 — 1.000 Q28204 →
Q08460 — 1.000 Q08460 →
O18867 — 1.000 O18867 →
O18866 — 1.000 O18866 →
Q62976 — 0.999 Q62976 →
Q28265 — 0.997 Q28265 →
B7ZC96 — 0.997 B7ZC96 →
Q03720 — 0.997 Q03720 →
Q90ZC7 — 0.997 Q90ZC7 →
Q8AYS8 — 0.994 Q8AYS8 →
Q95V25 — 0.992 Q95V25 →
Q60603 — 0.984 Q60603 →
D4A6Z8 — 0.984 D4A6Z8 →
A5LFX5 — 0.982 A5LFX5 →
A8MYU2 — 0.981 A8MYU2 →
KCNH1 Voltage-gated delayed rectifier potassium channel KCNH1 0.981 landscape →
Q63472 — 0.979 Q63472 →
Q9JIS8 — 0.979 Q9JIS8 →
O54982 — 0.979 O54982 →
Q9UHW9 — 0.978 Q9UHW9 →
P70604 — 0.978 P70604 →
Q8NCM2 — 0.978 Q8NCM2 →
Q8WSR4 — 0.978 Q8WSR4 →
DNAJC13 DnaJ homolog subfamily C member 13 0.978 landscape →
Q21029 — 0.977 Q21029 →
Q62398 — 0.977 Q62398 →
Q920E3 — 0.977 Q920E3 →
Q924N4 — 0.977 Q924N4 →
Q92503 — 0.977 Q92503 →