Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.37 |
| ▸ | HTR2B | P41595 | 3/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.31 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
| ▸ | CD44 | P16070 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11431108 | 0.92 | HTR2C (0.35) | HTR2CHTR2BHTR2AALDH1A1MEN1 | |
| SCHEMBL11436127 | 0.77 | NOTUM (0.40) | ALDH1A1MEN1KMT2AKDM1AADRB1 | |
| SCHEMBL11436328 | 0.75 | HTR2C (0.37) | HTR2CHTR2BHTR2AALDH1A1MEN1 | |
| SCHEMBL6501844 | 0.74 | ALDH1A1 (0.37) | ALDH1A1MEN1USP2CDK4ALOX15 | |
| SCHEMBL11436079 | 0.73 | HTR2C (0.35) | HTR2CHTR2BHTR2AALDH1A1MEN1 | |
| SCHEMBL11437627 | 0.72 | NOTUM (0.35) | HTR2CHTR2BHTR2AALDH1A1MEN1 | |
| SCHEMBL11434536 | 0.69 | HTR2A (0.44) | HTR2CHTR2AKMT2ATSHRADRB1 | |
| SCHEMBL10931076 | 0.67 | HTR2C (0.64) | HTR2CHTR2BHTR2ATSHRPNMT | |
| SCHEMBL11436384 | 0.67 | HTR2A (0.42) | HTR2CHTR2AKMT2ATSHRADRB1 | |
| SCHEMBL11437404 | 0.66 | ALDH1A1 (0.42) | ALDH1A1MEN1USP2CDK4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4238607-A | ANTIBIOTICS, SEDATIVES, HYPOTENSIVE AGENTS, AND ANTIDEPRESSANTS | ENDO LABORATORIES INC. (US) | 1980-12-09 | — | — | US | disclosed |
| US-4183936-A | SEDATIVES, ANTIDEPRESSANTS, HYPOTENSIVE AGENTS, BACTERICIDES | ENDO LABORATORIES, INC. (US) | 1980-01-15 | — | — | US | disclosed |
| US-4115577-A | SEDATIVES, ANTIDEPRESSANT ANTIHYPERTENSIVE, ANTIBACTERIAL | ENDO LABORATORIES, INC. (US) | 1978-09-19 | — | — | US | disclosed |
| US-4013652-A | SEDATIVES | ENDO LABORATORIES, INC. (US) | 1977-03-22 | — | — | US | disclosed |