Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | RGS12 | O14924 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11266282 | 0.79 | PARP1 (0.76) | KIF11LMNACYP3A4SLC6A2SLC6A4 | |
| Bromide SCHEMBL11274798 | 0.79 | PARP1 (0.76) | KIF11LMNACYP3A4SLC6A2SLC6A4 | |
| SCHEMBL11270095 | 0.77 | PARP1 (0.48) | KIF11LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL15096889 | 0.74 | CYP3A4 (1.00) | KIF11LMNACYP3A4CYP2D6MEN1 | |
| SCHEMBL1076323 | 0.74 | CYP3A4 (1.00) | KIF11LMNACYP3A4CYP2D6MEN1 | |
| SCHEMBL6010798 | 0.73 | CYP3A4 (0.66) | KIF11LMNACYP3A4CYP2D6MEN1 | |
| SCHEMBL980093 | 0.69 | MEN1 (0.75) | KIF11LMNACYP3A4CYP2D6MEN1 | |
| Nomifensine SCHEMBL29355061 | 0.69 | SLC6A2 (1.00) | KIF11LMNACYP3A4CYP2D6MEN1 | |
| Nomifensine SCHEMBL49380 | 0.69 | SLC6A2 (1.00) | KIF11LMNACYP3A4CYP2D6MEN1 | |
| SCHEMBL5691906 | 0.69 | SLC6A2 (0.54) | KIF11LMNACYP3A4CYP2D6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4185105-A | 4-Phenyl-8-amino-tetrahydroisoquinolines and antidepressant use | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-01-22 | — | — | US | claimed |
| EP-0000013-A1 | 4-Phenyl-8-amino-tetrahydroisoquinolines, pharmaceutical compositions containing them and process for preparation of these compositions | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-12-20 | — | — | EP | claimed |
| EP-0000013-B1 | 4-PHENYL-8-AMINO-TETRAHYDROISOQUINOLINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARATION OF THESE COMPOSITIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-10-15 | — | — | EP | disclosed |
| EP-0000013-B1 | 4-PHENYL-8-AMINO-TETRAHYDROISOQUINOLINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARATION OF THESE COMPOSITIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-10-15 | — | — | EP | disclosed |
| US-4185105-A | 4-Phenyl-8-amino-tetrahydroisoquinolines and antidepressant use | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-01-22 | — | — | US | disclosed |
| US-4185105-A | 4-Phenyl-8-amino-tetrahydroisoquinolines and antidepressant use | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-01-22 | — | — | US | disclosed |
| US-4185105-A | 4-Phenyl-8-amino-tetrahydroisoquinolines and antidepressant use | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-01-22 | — | — | US | disclosed |
| EP-0000013-A1 | 4-Phenyl-8-amino-tetrahydroisoquinolines, pharmaceutical compositions containing them and process for preparation of these compositions | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-12-20 | — | — | EP | disclosed |
| EP-0000013-A1 | 4-Phenyl-8-amino-tetrahydroisoquinolines, pharmaceutical compositions containing them and process for preparation of these compositions | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-12-20 | — | — | EP | disclosed |
| EP-0000013-A1 | 4-Phenyl-8-amino-tetrahydroisoquinolines, pharmaceutical compositions containing them and process for preparation of these compositions | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-12-20 | — | — | EP | disclosed |