Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nomifensine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 15/20 | 1.00 |
| ▸ | SLC6A4 known ✓ | P31645 | 15/20 | 1.00 |
| ▸ | SLC6A3 known ✓ | Q01959 | 15/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | RGS12 | O14924 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 1/20 | 1.00 |
| ▸ | HRH1 | P35367 | 1/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 1/20 | 1.00 |
| ▸ | GNAI1 | P63096 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.81 |
| ▸ | GLA | P06280 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nomifensine SCHEMBL125020 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3LMNAMAPK1 | |
| Nomifensine SCHEMBL29355061 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3LMNAMAPK1 | |
| Nomifensine SCHEMBL11082568 | 0.98 | SLC6A2 (0.97) | SLC6A2SLC6A4SLC6A3LMNAMAPK1 | |
| Nomifensine SCHEMBL125019 | 0.90 | LMNA (1.00) | SLC6A2SLC6A4SLC6A3LMNAMAPK1 | |
| Nomifensine SCHEMBL10538258 | 0.90 | LMNA (1.00) | SLC6A2SLC6A4SLC6A3LMNAMAPK1 | |
| SCHEMBL11013456 | 0.88 | SLC6A2 (0.79) | SLC6A2SLC6A4SLC6A3LMNAMAPK1 | |
| SCHEMBL9810092 | 0.87 | SLC6A2 (0.77) | SLC6A2SLC6A4SLC6A3LMNAMAPK1 | |
| SCHEMBL4035368 | 0.87 | SLC6A2 (0.77) | SLC6A2SLC6A4SLC6A3LMNAMAPK1 | |
| SCHEMBL22400710 | 0.87 | SLC6A2 (0.76) | SLC6A2SLC6A4SLC6A3LMNAMAPK1 | |
| Bromide SCHEMBL11267146 | 0.86 | SLC6A2 (0.75) | SLC6A2SLC6A4SLC6A3LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 7661 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026106917-A1 | EDIBLE TRANSMUCOSAL DRUG DELIVERY METHOD USING AN INTERMEDIATE CAPSULE AS A TEMPORARY VESSEL | BioPhysics Pharma, Inc. (US) | 2026-05-21 | — | — | WO | claimed |
| US-12605345-B2 | Transdermal drug delivery system | BioPhysics Pharma, Inc. (US) | 2026-04-21 | — | — | US | claimed |
| US-20260001942-A1 | TREATMENT OF HEADACHE DISORDERS AND/OR PSYCHIATRIC SYMPTOMS USING ANTI-CGRP ANTIBODIES, AND COMPOSITIONS AND METHODS RELATED THERETO | H LUNDBECK AS (DK) | 2026-01-01 | — | — | US | claimed |
| WO-2025262247-A1 | TREATMENT OF HEADACHE DISORDERS AND/OR PSYCHIATRIC SYMPTOMS USING ANTI-CGRP ANTIBODIES, AND COMPOSITIONS AND METHODS RELATED THERETO | H. LUNDBECK A/S (DK) | 2025-12-26 | — | — | WO | claimed |
| EP-4633638-A1 | TREATMENT OF PSYCHOLOGICAL FACTORS AFFECTING OTHER MEDICAL CONDITIONS (PFAOMC) | Luminous Mind Inc. (US) | 2025-10-22 | — | — | EP | claimed |
| EP-4615506-A1 | USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES | Sahin, Fikret (TR) | 2025-09-17 | — | — | EP | claimed |
| US-20250268841-A1 | Trans-Epithelial Membrane Drug Delivery System | Masiz, John J. (US) | 2025-08-28 | — | — | US | claimed |
| WO-2025151884-A1 | USE OF GLYCOSAMINOGLYCAN SULFATED POLYSACCHARIDES SUCH AS SODIUM PENTOSAN POLYSULFATE IN COMBINATION WITH PERMEATION AGENTS TO TREAT ALZHEIMER'S DISEASE | PARSONS C LOWELL (US) | 2025-07-17 | — | — | WO | claimed |
| US-20250120907-A1 | Transmucosal Drug Delivery System | Masiz, John J. (US) | 2025-04-17 | — | — | US | claimed |
| EP-4525870-A1 | METHODS OF TREATING CUSHING'S SYNDROME AND LIVER DISORDERS, AND OF REDUCING LIVER TOXICITY OF OTHER DRUGS ADMINISTERED TO A PATIENT | Corcept Therapeutics Incorporated (US) | 2025-03-26 | — | — | EP | claimed |
| EP-0161501-B1 | ANTI-ULCER MEANS FOR THE TREATMENT OF ABSCESSES | T P O "PHARMACHIM" (BG) | 1989-03-15 | — | — | EP | claimed |
| US-4806548-A | 4-PHENYL-TETRAHYDROISOQUINOLINE ANTIDEPRESSANT, CIMETIDINE, AND RANITIDINE; HISTAMINE H-2-ANTAGONISTS | T P O PHARMACHIM (BG) | 1989-02-21 | — | — | US | claimed |
| CN-1003045-B | Synthesis of intermediate amino alcohol of antidepressant Nomifensin | TIANJING PHARMACEUTICAL INST S (CN) | 1989-01-11 | — | — | CN | claimed |
| CN-1003013-B | Synthesis of nitro acetophenone hydrochloride as intermediate of antidepressant Nomifenin | 国家医药管理局天津药物研究院 | 1989-01-04 | — | — | CN | claimed |
| WO-1988007684-A2 | INFRARED IMMUNOLOGICAL DOSING | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS (FR) | 1988-10-06 | — | — | WO | claimed |
| CN-86108706-A | Synthesizing of alchol of antimelancholic ' Nomifensin ' intermediate nitro-acetophenone hydrochloride | — | 1987-12-23 | — | — | CN | claimed |
| EP-0161501-A1 | Anti-ulcer means for the treatment of abscesses | T P O "PHARMACHIM" (BG) | 1985-11-21 | — | — | EP | claimed |
| EP-0089948-B1 | PHARMACEUTICAL COMPOSITIONS | COPPEN, Alec James (GB) | 1985-08-14 | — | — | EP | claimed |
| EP-0120438-A1 | Optical antipodes of 8-amino-2-methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinoline, process for its preparation and pharmaceutical compositions having an anti-depressive action containing it | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-10-03 | — | — | EP | claimed |
| US-4207309-A | FOR DIFFERENTIATING BETWEEN HYPERPROLACTINEMIA DUE TO PITUITARY TUMORS AND FUNCTIONAL CASES | MULLER EUGENIO E | 1980-06-10 | — | — | US | claimed |