⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16569728 | 1.00 | — | — | |
| SCHEMBL1144580 | 0.84 | — | — | |
| SCHEMBL9756456 | 0.78 | — | — | |
| SCHEMBL181080 | 0.78 | — | — | |
| SCHEMBL289020 | 0.76 | — | — | |
| SCHEMBL7802027 | 0.73 | — | — | |
| SCHEMBL1853681 | 0.73 | — | — | |
| SCHEMBL22093036 | 0.71 | — | — | |
| SCHEMBL21085136 | 0.71 | POLB (0.40) | — | |
| SCHEMBL1144089 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143216-A | Antibacterial biaromatic derivatives | ACTELION PHARMACEUTICALS LTD | 2015-12-09 | — | — | CN | claimed |
| US-7115648-B2 | Indole-amide derivatives and their use as glycogen phosphorylase inhibitors | ASTRAZENECA AB (SE) | 2006-10-03 | — | — | US | claimed |
| US-20050159472-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | US | claimed |
| EP-1483239-A2 | INDOLE-AMIDE DERIVATIVES AND THEIR USE AS GLYCOGEN PHOSPHORYLASE INHIBITORS | Astrazeneca AB (SE) | 2004-12-08 | — | — | EP | claimed |
| WO-2003074485-A2 | INDOLE-AMIDE DERIVATIVES AND THEIR USE AS GLYCOGEN PHOSPHORYLASE INHIBITORS | ASTRAZENECA AB (SE) | 2003-09-12 | — | — | WO | claimed |
| US-4217361-A | Disubstituted xanthone-2-carboxylic acid antiallergy agents | SYNTEX (U.S.A.) INC. (US) | 1980-08-12 | — | — | US | claimed |
| EP-3512852-B1 | TRAF 6 INHIBITORS | HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM GESUNDHEIT & UMWELT GMBH (DE) | 2024-06-26 | — | — | EP | disclosed |
| EP-3871673-B1 | NOVEL INDAZOLE COMPOUND OR SALT THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2024-01-03 | — | — | EP | disclosed |
| CN-110740991-B | Novel biphenyl compound or salt thereof | 大鹏药品工业株式会社 | 2023-07-04 | — | — | CN | disclosed |
| US-20230181536-A1 | ANTICANCER COMBINATION THERAPY WITH N-(1-ACRYLOYL-AZETIDIN-3-YL)-2-((1H-INDAZOL-3-YL)AMINO)METHYL)-1H-IMIDAZOLE-5-CARBOXAMIDE INHIBITOR OF KRAS-G12C | TAIHO PHARMACEUTICAL CO LTD (JP) | 2023-06-15 | — | — | US | disclosed |
| EP-3632443-B1 | ANTI-TUMOR EFFECT POTENTIATOR USING A BIPHENYL COMPOUND | TAIHO PHARMACEUTICAL CO LTD (JP) | 2023-06-07 | — | — | EP | disclosed |
| EP-3381896-B1 | BIPHENYL COMPOUND OR SALT THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2023-01-18 | — | — | EP | disclosed |
| CN-109715631-B | TRAF6 inhibitors | 德国亥姆霍兹慕尼黑中心健康与环境研究中心（有限公司） | 2022-02-18 | — | — | CN | disclosed |
| US-20040167131-A1 | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade | PFIZER INC. | 2004-08-26 | — | — | US | disclosed |
| WO-2004024679-A1 | INHIBITORS OF FACTOR XA AND OTHER SERINE PROTEASES INVOLVED IN THE COAGULATION CASCADE | WARNER-LAMBERT COMPANY LLC (US) | 2004-03-25 | — | — | WO | disclosed |
| US-6642241-B1 | Alkylamino- substituted dihydropyrimido-(4,5-d)pyrimidinone derivatives, inhibitors of p38, | SYNTEX (U.S.A.) LLC | 2003-11-04 | — | — | US | disclosed |
| WO-2003074485-A2 | INDOLE-AMIDE DERIVATIVES AND THEIR USE AS GLYCOGEN PHOSPHORYLASE INHIBITORS | ASTRAZENECA AB (SE) | 2003-09-12 | — | — | WO | disclosed |
| EP-1226144-A1 | ALKYLAMINO SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001029041-A1 | ALKYLAMINO SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |
| US-4217361-A | Disubstituted xanthone-2-carboxylic acid antiallergy agents | SYNTEX (U.S.A.) INC. (US) | 1980-08-12 | — | — | US | disclosed |