SCHEMBL11445441

SCHEMBL11445441

O=C1Nc2ccc(F)cc2N2CCNCC12

nearest known ligand 0.74

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 16/20 0.74
ALDH1A1 P00352 3/20 0.65
HTR2A P28223 2/20 0.65
CYP1A2 P05177 1/20 0.65
CYP3A4 P08684 1/20 0.65
CYP2D6 P10635 1/20 0.65
CYP2C9 P11712 1/20 0.65
CYP2C19 P33261 1/20 0.65
KMT2A Q03164 2/20 0.48
HTR2B P41595 4/20 0.48
KDM4E B2RXH2 2/20 0.43
MAPT P10636 2/20 0.43
GAA P10253 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.42
MEN1 O00255 1/20 0.39
HTR6 P50406 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11445688 0.89 HTR2C (0.71) HTR2CALDH1A1HTR2ACYP1A2CYP3A4
SCHEMBL11454097 0.85 HTR2C (0.72) HTR2CALDH1A1HTR2ACYP1A2CYP3A4
SCHEMBL5872618 0.85 HTR2C (1.00) HTR2CALDH1A1HTR2ACYP1A2CYP3A4
SCHEMBL5872615 0.85 HTR2C (1.00) HTR2CALDH1A1HTR2ACYP1A2CYP3A4
Hydrochloric Acid SCHEMBL7053381 0.84 HTR2C (0.97) HTR2CALDH1A1HTR2ACYP1A2CYP3A4
Hydrochloric Acid SCHEMBL7053385 0.84 HTR2C (0.97) HTR2CALDH1A1HTR2ACYP1A2CYP3A4
SCHEMBL5872565 0.83 HTR2C (1.00) HTR2CALDH1A1HTR2ACYP1A2CYP3A4
Hydrochloric Acid SCHEMBL5872569 0.82 HTR2C (0.97) HTR2CALDH1A1HTR2ACYP1A2CYP3A4
SCHEMBL11453721 0.82 HTR2C (0.67) HTR2CALDH1A1HTR2ACYP1A2CYP3A4
SCHEMBL25045478 0.81 HTR2C (0.67) HTR2CALDH1A1HTR2ACYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4089958-A HYPOTENSIVE AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1978-05-16 US claimed
US-4032639-A 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2-a,]quinoxalin-5(6H)-ones and derivatives thereof for relieving hypertension AMERICAN HOME PRODUCTS CORPORATION (US) 1977-06-28 US claimed
US-4182872-A CORRESPONDING 4-CARBOBENZOXY COMPOUNDS, 2,3,4,4A-TETRAHYDRO-1H-PYRAZINO(1,2-A)QUINOXALIN-5(6H)-ONES, 2,3,4,4A,5,6-HEXAHYDRO-1H-PYRAZINO(1,2-A)QUINOXALINES, HYPOTENSIVE AMERICAN HOME PRODUCTS CORPORATION (US) 1980-01-08 US disclosed
US-4182869-A HYPOTENSIVE AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1980-01-08 US disclosed
US-4138567-A HYPOTENSIVE AMERICAN HOME PRODUCTS CORPORATION (US) 1979-02-06 US disclosed
US-4089958-A HYPOTENSIVE AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1978-05-16 US disclosed
US-4032639-A 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2-a,]quinoxalin-5(6H)-ones and derivatives thereof for relieving hypertension AMERICAN HOME PRODUCTS CORPORATION (US) 1977-06-28 US disclosed