Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 17/20 | 1.00 |
| ▸ | HTR2A | P28223 | 7/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | HTR2B | P41595 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872615 | 1.00 | HTR2C (1.00) | HTR2CHTR2AALDH1A1CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL7053381 | 0.99 | HTR2C (0.97) | HTR2CHTR2AALDH1A1CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL7053385 | 0.99 | HTR2C (0.97) | HTR2CHTR2AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL11455825 | 0.89 | HTR2C (0.81) | HTR2CHTR2AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL11445441 | 0.85 | HTR2C (0.74) | HTR2CHTR2AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL11454097 | 0.84 | HTR2C (0.72) | HTR2CHTR2AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL255572 | 0.83 | HTR2C (1.00) | HTR2CHTR2AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL29391309 | 0.83 | HTR2C (1.00) | HTR2CHTR2AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL5872568 | 0.83 | HTR2C (1.00) | HTR2CHTR2AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL905974 | 0.83 | HTR2C (1.00) | HTR2CHTR2AALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6706714-B2 | USEFUL FOR THE TREATMENT OF DISORDERS INVOLVING THE CENTRAL NERVOUS SYSTEM SUCH AS OBSESSIVE-COMPULSIVE DISORDER, DEPRESSION, ANXIETY, SCHIZOPHERNIA, MIGRAINE, SLEEP OR EATING DISORDER, OBESITY, TYPE II DIABETES AND EPILEPSY | WYETH CORP (US) | 2004-03-16 | — | — | US | claimed |
| US-20030060468-A1 | 2,3,4,4a-Tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)one derivatives | WYETH (US) | 2003-03-27 | — | — | US | claimed |
| US-20010051622-A1 | 2,3,4,4a-tetrahydro-1H-pyrazino-[1,2a] quinoxalin-5- (6H) one derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-12-13 | — | — | US | claimed |
| US-4089958-A | HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1978-05-16 | — | — | US | claimed |
| US-4032639-A | 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2-a,]quinoxalin-5(6H)-ones and derivatives thereof for relieving hypertension | AMERICAN HOME PRODUCTS CORPORATION (US) | 1977-06-28 | — | — | US | claimed |
| US-7098338-B2 | 2,3,4,4a-tetrahydro-1H-pyrazino(1,2-a) quinoxalin-5(6H)one derivatives | WYETH (US) | 2006-08-29 | — | — | US | disclosed |
| US-20040116437-A1 | 2,3,4,4a-tetrahydro-1H-pyrazino(1,2-a) quinoxalin-5(6H)one derivatives | WYETH (US) | 2004-06-17 | — | — | US | disclosed |
| US-6706714-B2 | USEFUL FOR THE TREATMENT OF DISORDERS INVOLVING THE CENTRAL NERVOUS SYSTEM SUCH AS OBSESSIVE-COMPULSIVE DISORDER, DEPRESSION, ANXIETY, SCHIZOPHERNIA, MIGRAINE, SLEEP OR EATING DISORDER, OBESITY, TYPE II DIABETES AND EPILEPSY | WYETH CORP (US) | 2004-03-16 | — | — | US | disclosed |
| US-20030060468-A1 | 2,3,4,4a-Tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)one derivatives | WYETH (US) | 2003-03-27 | — | — | US | disclosed |
| US-6476032-B2 | 5HT2C RECEPTOR AGONISTS TO TREAT SCHIZOPHRENIA AND CENTRAL NERVOUS SYSTEM DISORDERS; OBSESSIVE-COMPULSIVE DISORDER; ANTIDEPRESSANTS, MIGRAINE; SLEEP DISORDERS; EATING DISORDERS; OBESITY; ANTIDIABETIC, -EPILEPTIC AND ANXIOLYTIC AGENTS | WYETH | 2002-11-05 | — | — | US | disclosed |
| US-6372745-B1 | TREATMENT OF OBESITY IN MAMMALS | AMERICAN HOME PRODUCTS CORPORATION | 2002-04-16 | — | — | US | disclosed |
| US-20010051622-A1 | 2,3,4,4a-tetrahydro-1H-pyrazino-[1,2a] quinoxalin-5- (6H) one derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-12-13 | — | — | US | disclosed |
| US-4182872-A | CORRESPONDING 4-CARBOBENZOXY COMPOUNDS, 2,3,4,4A-TETRAHYDRO-1H-PYRAZINO(1,2-A)QUINOXALIN-5(6H)-ONES, 2,3,4,4A,5,6-HEXAHYDRO-1H-PYRAZINO(1,2-A)QUINOXALINES, HYPOTENSIVE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-01-08 | — | — | US | disclosed |
| US-4182869-A | HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-01-08 | — | — | US | disclosed |
| US-4138567-A | HYPOTENSIVE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1979-02-06 | — | — | US | disclosed |
| US-4089958-A | HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1978-05-16 | — | — | US | disclosed |
| US-4032639-A | 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2-a,]quinoxalin-5(6H)-ones and derivatives thereof for relieving hypertension | AMERICAN HOME PRODUCTS CORPORATION (US) | 1977-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030060468-A1 | 2,3,4,4a-Tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)one derivatives | NPY2R, HCRTR2, HTR2C | HTR2C 3/4885HTR2A 10/4885ALDH1A1 1969/4885 |
| US-20010051622-A1 | 2,3,4,4a-tetrahydro-1H-pyrazino-[1,2a] quinoxalin-5- (6H) one derivatives | HTR2C, HTR3C, NPY2R | HTR2C 1/4885HTR2A 5/4885ALDH1A1 2135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.