Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MITF | O75030 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11447829 | 0.97 | ALDH1A1 (0.45) | ALDH1A1KMT2ASMN1; SMN2MITFMEN1 | |
| SCHEMBL11446840 | 0.97 | ALDH1A1 (0.45) | ALDH1A1KMT2ASMN1; SMN2MITFMEN1 | |
| SCHEMBL11465725 | 0.97 | ALDH1A1 (0.45) | ALDH1A1KMT2ASMN1; SMN2MITFMEN1 | |
| Maleic Acid SCHEMBL11447588 | 0.91 | NPC1 (0.40) | ALDH1A1KMT2ASMN1; SMN2MITFMEN1 | |
| SCHEMBL11341207 | 0.89 | ALDH1A1 (0.46) | ALDH1A1KMT2ASMN1; SMN2MITFMEN1 | |
| SCHEMBL11336631 | 0.89 | ALDH1A1 (0.46) | ALDH1A1KMT2ASMN1; SMN2MITFMEN1 | |
| SCHEMBL11332173 | 0.89 | ALDH1A1 (0.46) | ALDH1A1KMT2ASMN1; SMN2MITFMEN1 | |
| SCHEMBL11446546 | 0.88 | ALDH1A1 (0.44) | ALDH1A1KMT2ASMN1; SMN2MITFMEN1 | |
| Hydrochloric Acid SCHEMBL11573548 | 0.88 | ALDH1A1 (0.45) | ALDH1A1KMT2ASMN1; SMN2MITFMEN1 | |
| SCHEMBL11446846 | 0.87 | ALDH1A1 (0.43) | ALDH1A1KMT2ASMN1; SMN2MITFMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4204003-A | N-(2-Aminocyclopentyl)-N-alkanoylanilides as CNS anti-depressants | THE UPJOHN COMPANY (US) | 1980-05-20 | — | — | US | disclosed |
| US-4156733-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-05-29 | — | — | US | disclosed |
| US-4156015-A | N-(2-Aminocyclopentyl)acylanilides and treating depression | THE UPJOHN COMPANY (US) | 1979-05-22 | — | — | US | disclosed |