Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 2/20 | 0.55 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11448897 | 0.97 | CHRNB4 (0.52) | CHRNB4CHRNA3ALDH1A1LMNAKDM4E | |
| SCHEMBL1928412 | 0.87 | CHRNB4 (0.72) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4 | |
| SCHEMBL1928695 | 0.87 | CHRNB4 (0.72) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4 | |
| SCHEMBL14578238 | 0.85 | CHRNB4 (0.61) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4 | |
| SCHEMBL11455709 | 0.84 | CHRNB4 (0.76) | CHRNB4CHRNA3ALDH1A1CHRNB1CHRNB2 | |
| SCHEMBL11448305 | 0.84 | TDP1 (0.57) | CHRNB4CHRNA3ALDH1A1KDM4ETDP1 | |
| SCHEMBL14578289 | 0.83 | CHRNB4 (0.58) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4 | |
| SCHEMBL11449643 | 0.83 | CHRNB4 (0.55) | CHRNB4CHRNA3LMNACHRNB1CHRNB2 | |
| SCHEMBL1929302 | 0.83 | CHRNB4 (0.66) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4 | |
| SCHEMBL11447873 | 0.83 | CHRNB4 (0.55) | CHRNB4CHRNA3ALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4225608-A | ANTIDEPRESSANTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-09-30 | — | — | US | disclosed |