Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 4/20 | 0.60 |
| ▸ | CDK8 | P49336 | 4/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.37 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | TTK | P33981 | 2/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11448005 | 0.83 | CCNC (0.60) | CCNCCDK8AURKBINCENPAURKA | |
| SCHEMBL11450026 | 0.80 | CCNC (0.56) | CCNCCDK8AURKBINCENPAURKA | |
| SCHEMBL11450302 | 0.80 | CCNC (0.70) | CCNCCDK8PDE3BPDE3AKDM4E | |
| SCHEMBL11239434 | 0.79 | CCNC (0.55) | CCNCCDK8AURKBINCENPAURKA | |
| SCHEMBL11449031 | 0.79 | CCNC (0.55) | CCNCCDK8AURKBINCENPAURKA | |
| SCHEMBL11457708 | 0.78 | CCNC (0.54) | CCNCCDK8AURKBINCENPAURKA | |
| SCHEMBL11448518 | 0.77 | CCNC (0.58) | CCNCCDK8PDE3BPDE3AKDM4E | |
| SCHEMBL11244387 | 0.75 | CCNC (0.47) | CCNCCDK8ALDH1A1LMNARPS6KA3 | |
| SCHEMBL11450001 | 0.74 | TTK (0.64) | CCNCCDK8AURKBINCENPAURKA | |
| SCHEMBL11219764 | 0.73 | CCNC (0.51) | CCNCCDK8AURKBINCENPAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4225715-A | Preparation of 3-amino(or carbamyl)-5-(pyridinyl)-2(1H)-pyridinones | STERLING DRUG INC. (US) | 1980-09-30 | — | — | US | disclosed |
| US-4199586-A | Di-(lower-alkyl) N-[1,2-dihydro-2-oxo-5-(pyridinyl)-3-pyridinyl]amino-methylanemalonates | STERLING DRUG INC. (US) | 1980-04-22 | — | — | US | disclosed |
| US-4137233-A | 1,2-Dihydro-2-oxo-5-(pyridinyl)nicotinamides | STERLING DRUG INC. (US) | 1979-01-30 | — | — | US | disclosed |
| US-4107315-A | 5-(Pyridinyl)-2(1H)-pyridinones | STERLING DRUG INC. (US) | 1978-08-15 | — | — | US | disclosed |
| US-4072746-A | CARDIOTONIC AGENTS | STERLING DRUG INC. (US) | 1978-02-07 | — | — | US | disclosed |