Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 2/20 | 0.54 |
| ▸ | CDK8 | P49336 | 2/20 | 0.54 |
| ▸ | ITK | Q08881 | 7/20 | 0.42 |
| ▸ | KDM6B | O15054 | 2/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.41 |
| ▸ | LATS1 | O95835 | 2/20 | 0.39 |
| ▸ | ECE1 | P42892 | 1/20 | 0.38 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 4/20 | 0.37 |
| ▸ | TTK | P33981 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.35 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11448005 | 0.78 | CCNC (0.60) | CCNCCDK8ITKTTKAURKB | |
| SCHEMBL11448149 | 0.78 | CCNC (0.60) | CCNCCDK8ITKLATS1TTK | |
| SCHEMBL11231633 | 0.78 | CCNC (0.48) | CCNCCDK8ITKTTKAURKB | |
| SCHEMBL11219760 | 0.78 | CCNC (0.51) | CCNCCDK8ITKTTKAURKB | |
| SCHEMBL11219764 | 0.78 | CCNC (0.51) | CCNCCDK8ITKTTKAURKB | |
| SCHEMBL11231636 | 0.78 | CCNC (0.48) | CCNCCDK8ITKTTKAURKB | |
| SCHEMBL11450026 | 0.75 | CCNC (0.56) | CCNCCDK8ITKKDM6BKDM4C | |
| SCHEMBL11450302 | 0.75 | CCNC (0.70) | CCNCCDK8 | |
| SCHEMBL11449031 | 0.74 | CCNC (0.55) | CCNCCDK8ITKTTKAURKB | |
| SCHEMBL11239434 | 0.74 | CCNC (0.55) | CCNCCDK8ITKTTKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4225715-A | Preparation of 3-amino(or carbamyl)-5-(pyridinyl)-2(1H)-pyridinones | STERLING DRUG INC. (US) | 1980-09-30 | — | — | US | disclosed |
| US-4199586-A | Di-(lower-alkyl) N-[1,2-dihydro-2-oxo-5-(pyridinyl)-3-pyridinyl]amino-methylanemalonates | STERLING DRUG INC. (US) | 1980-04-22 | — | — | US | disclosed |
| US-4137233-A | 1,2-Dihydro-2-oxo-5-(pyridinyl)nicotinamides | STERLING DRUG INC. (US) | 1979-01-30 | — | — | US | disclosed |
| US-4107315-A | 5-(Pyridinyl)-2(1H)-pyridinones | STERLING DRUG INC. (US) | 1978-08-15 | — | — | US | disclosed |
| US-4072746-A | CARDIOTONIC AGENTS | STERLING DRUG INC. (US) | 1978-02-07 | — | — | US | disclosed |