Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11466350 | 0.87 | HTR2C (0.40) | KDM4EALDH1A1SMN1; SMN2HRH3FPR2 | |
| SCHEMBL11466696 | 0.87 | HRH3 (0.47) | SMN1; SMN2HRH3 | |
| SCHEMBL11447888 | 0.87 | HTT (0.45) | ALDH1A1RAB9AHRH3HPGD | |
| SCHEMBL11448945 | 0.85 | HRH3 (0.46) | SMN1; SMN2HRH3 | |
| SCHEMBL11448121 | 0.85 | MAPT (0.42) | KDM4EALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL11447694 | 0.85 | HTT (0.36) | KDM4EALDH1A1HRH3ATML3MBTL1 | |
| SCHEMBL11455667 | 0.85 | FPR2 (0.48) | HRH3L3MBTL1FPR2PROKR1 | |
| SCHEMBL11458402 | 0.85 | ATM (0.43) | ATML3MBTL1CHRNA7 | |
| SCHEMBL11466703 | 0.84 | HRH3 (0.44) | SMN1; SMN2HRH3 | |
| SCHEMBL11448735 | 0.84 | KDM4E (0.45) | KDM4EALDH1A1SMN1; SMN2RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4225608-A | ANTIDEPRESSANTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-09-30 | — | — | US | disclosed |
| EP-0004288-A2 | Phenoxyalkyl amines, pharmaceutical compositions containing them, and process for their preparation | MERCK PATENT GmbH (DE) | 1979-10-03 | — | — | EP | disclosed |