Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | GHSR | Q92847 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11467441 | 0.96 | CHRNB4 (0.46) | CHRNB4CHRNA3ACHECYP3A4LMNA | |
| SCHEMBL11447454 | 0.87 | CHEK2 (0.46) | CHEK2 | |
| SCHEMBL11466687 | 0.84 | CHEK2 (0.50) | CHEK2 | |
| SCHEMBL11455784 | 0.83 | CHRNB4 (0.52) | CHRNB4CHRNA3GHSR | |
| SCHEMBL14578215 | 0.82 | CHRNB4 (0.52) | CHRNB4CHRNA3CHEK2 | |
| SCHEMBL11455927 | 0.81 | CHRNB4 (0.52) | CHRNB4CHRNA3GHSR | |
| SCHEMBL11458259 | 0.81 | CHRNB4 (0.75) | CHRNB4CHRNA3 | |
| SCHEMBL11466376 | 0.80 | CHRNB4 (0.51) | CHRNB4CHRNA3CYP3A4GHSR | |
| SCHEMBL11449447 | 0.80 | CYP1A2 (0.48) | CHRNB4CHRNA3 | |
| SCHEMBL5728990 | 0.79 | CHEK2 (0.48) | CHRNB4CHRNA3CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4225608-A | ANTIDEPRESSANTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-09-30 | — | — | US | disclosed |