Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 4/20 | 0.55 |
| ▸ | DRD5 | P21918 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | HTR2A | P28223 | 9/20 | 0.47 |
| ▸ | HTR2C | P28335 | 9/20 | 0.47 |
| ▸ | HTR2B | P41595 | 9/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29010853 | 0.82 | KMT2A (0.63) | MEN1KMT2ASMN1; SMN2MAPK1TSHR | |
| SCHEMBL11451984 | 0.81 | DRD1 (0.51) | DRD1DRD5MEN1KMT2AHTR2A | |
| Hydrochloric Acid SCHEMBL29010954 | 0.81 | KMT2A (0.61) | MEN1KMT2ASMN1; SMN2MAPK1TSHR | |
| SCHEMBL11452364 | 0.80 | DRD1 (0.64) | DRD1DRD5MAPK1 | |
| SCHEMBL7320752 | 0.80 | DRD1 (0.81) | DRD1DRD5MEN1KMT2AMAPK1 | |
| SCHEMBL7620194 | 0.80 | DRD1 (0.81) | DRD1DRD5MEN1KMT2AMAPK1 | |
| SCHEMBL7621209 | 0.80 | DRD1 (0.81) | DRD1DRD5MEN1KMT2AMAPK1 | |
| Hydrochloric Acid SCHEMBL11451993 | 0.80 | DRD1 (0.50) | DRD1DRD5MEN1KMT2AHTR2A | |
| Bromide SCHEMBL11452031 | 0.79 | DRD1 (0.65) | DRD1DRD5MAPK1 | |
| SCHEMBL11460890 | 0.79 | MEN1 (0.44) | DRD1DRD5MEN1KMT2AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4187314-A | DOPAMINERGIC ACTIVITY | SMITHKLINE CORPORATION (US) | 1980-02-05 | — | — | US | disclosed |
| US-4172890-A | CARDIOVASCULAR, PARKINSON'S DISEASE, DOPAMINERGIC | SMITHKLINE CORPORATION (US) | 1979-10-30 | — | — | US | disclosed |
| US-4111957-A | DOPAMINERGIC | SMITHKLINE CORPORATION (US) | 1978-09-05 | — | — | US | disclosed |
| US-4108989-A | TREATING PARKINSON*S DISEASE, CARDIOVASCULAR DISORDERS | SMITHKLINE CORPORATION (US) | 1978-08-22 | — | — | US | disclosed |