Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 4/20 | 0.39 |
| ▸ | GCGR | P47871 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | FABP3 | P05413 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11451924 | 0.88 | GPR139 (0.37) | GPR139GCGRMAPTFABP3FABP4 | |
| SCHEMBL11463589 | 0.82 | MAP3K14 (0.43) | GPR139GCGRLMNAALDH1A1HPGD | |
| SCHEMBL11462608 | 0.80 | GCGR (0.39) | GPR139GCGRMAPTDHODHTP53 | |
| SCHEMBL11465039 | 0.79 | GCGR (0.40) | GPR139GCGRMAPTDHODHTP53 | |
| SCHEMBL11461875 | 0.78 | MAPT (0.38) | GPR139GCGRMAPTALDH1A1KDM4E | |
| SCHEMBL11452563 | 0.78 | GCGR (0.33) | GPR139GCGRMAPTFABP3FABP4 | |
| SCHEMBL11509039 | 0.77 | GPR139 (0.37) | GPR139MAPTLMNAGAAMAPK1 | |
| SCHEMBL11459811 | 0.77 | GCGR (0.39) | GPR139GCGRMAPTDHODHTP53 | |
| SCHEMBL11453337 | 0.76 | PDE2A (0.39) | LMNAPOLBALDH1A1KDM4E | |
| SCHEMBL11454347 | 0.74 | MAP3K14 (0.41) | GPR139GCGRMAPTTP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4207325-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE AND ANTITHROMBOTIC PROPERTIES | BAYER AKTIENGESELLSCHAFT (DE) | 1980-06-10 | — | — | US | disclosed |
| US-4207335-A | ANTIALLERGENS | BEECHAM GROUP LIMITED (GB) | 1980-06-10 | — | — | US | disclosed |
| US-4113872-A | DIURETICS, SALURETICS, ANTIHYPERTENSIVE, ANTITHROMBOTIC AGENTS | BAKER AKTIENGESELLSHAFT (DE) | 1978-09-12 | — | — | US | disclosed |
| US-4112109-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE, ANTITHROMBOTIC | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-05 | — | — | US | disclosed |
| US-4099011-A | DIURETIC, SALURETIC, HYPOTENSIVE, ANTITHROMBOTIC | BAYER AKTIENGESELLSCHAFT (DE) | 1978-07-04 | — | — | US | disclosed |