GPR139 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL246581	0.59	18/20
SCHEMBL306577	0.42	16/20
SCHEMBL309311	0.40	16/20
SCHEMBL309312	0.40	16/20
SCHEMBL877268	0.55	15/20
SCHEMBL874810	0.52	15/20
SCHEMBL307308	0.41	15/20
SCHEMBL307417	0.41	15/20
SCHEMBL306816	0.41	15/20
SCHEMBL307203	0.39	15/20
SCHEMBL308183	0.39	15/20
SCHEMBL307213	0.38	15/20
SCHEMBL307584	0.37	15/20
SCHEMBL876799	0.51	14/20
SCHEMBL307996	0.40	14/20
SCHEMBL307997	0.40	14/20
SCHEMBL308087	0.40	14/20
SCHEMBL308036	0.40	14/20
SCHEMBL308037	0.40	14/20
SCHEMBL306885	0.37	14/20

Clinical trials — most relevant to GPR139 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
Effects of Genotype on Resting State Connectivity During Methamphetamine Administration	PHASE4	COMPLETED
the Efficacy and Safety of Oliceridine Fumarate Injection for Acute Pain After Abdominal Surgery	PHASE4	NOT_YET_RECRUITING
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
The Role of Endocannabinoids in Insulin Production and Action	PHASE1	COMPLETED
A Single Ascending Dose Escalation to Investigate Safety and PK of VVZ-149 Injection in Healthy Older Male Volunteers	PHASE1	COMPLETED
PET Brain and Whole Body Distribution Studies for Nociceptin/Orphanin FQ Peptide (NOP) Receptor Using [11C]NOP-1A	EARLY_PHASE1	COMPLETED
GPR109A and Parkinson's Disease: Role of Niacin in Outcome Measures	nan	COMPLETED
Brain Receptors in Sympathetic Nervous System Regulation	nan	COMPLETED
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance	nan	UNKNOWN
Oat Bran and Plasma Lipid and Fecal Bacteria in Coronary Artery Disease Patients	nan	COMPLETED
Genetic Influences of Albuterol Response In Children With Bronchiolitis	nan	COMPLETED
-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans.	nan	COMPLETED
Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms	nan	COMPLETED
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism.	nan	NOT_YET_RECRUITING
Forced Oscillometry in Infants With Bronchopulmonary Dysplasia	nan	RECRUITING
Effects of Probiotics on Gut Microbiota, Endocannabinoid and Immune Activation and Symptoms of Fatigue in Dancers	nan	COMPLETED
Gastroparesis Registry 3	nan	COMPLETED
Fat-induced Release of GLP-1 in Humans	nan	COMPLETED
FFAR Agonist on Incretins, Insulin, Lipids and Inflammation	nan	COMPLETED
Metabotropic Receptors For Glutamate Type 3 In Parkinson's	nan	UNKNOWN
Vulvodynia: Identification of Potential Relevant Biomarkers	nan	COMPLETED
GABRA2 and the Pharmacokinetics of Risk for Alcoholism (GPRA)	nan	COMPLETED
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein	nan	COMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
Selective Activation of the Adrenomedullin Receptors in Migraine	nan	NOT_YET_RECRUITING
B2 Adrenergic Receptor Gene Polymorphism in Bronchial Asthma	nan	UNKNOWN
The Role of Stromal Cell-Derived Factor-1 (SDF-1)/CXC Chemokine Receptor 4 (CXCR4) in Metastasis of Laryngeal and Hypopharyngeal Squamous Cell Carcinoma	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a GPR139 binder may also engage these)

Protein	Name	Similarity
P0C0W8	—	0.999	P0C0W8 →
Q80UC8	—	0.996	Q80UC8 →
Q99680	—	0.975	Q99680 →
Q5U431	—	0.971	Q5U431 →
Q8BZL4	—	0.970	Q8BZL4 →
GPR39	G-protein coupled receptor 39	0.969	landscape →
D4A3U0	—	0.967	D4A3U0 →
B4XF06	—	0.967	B4XF06 →
NMUR2	Neuromedin-U receptor 2	0.966	landscape →
Q91178	—	0.963	Q91178 →
B2ZHY2	—	0.962	B2ZHY2 →
Q9Y5Y3	—	0.962	Q9Y5Y3 →
A0A2R9YJI3	—	0.961	A0A2R9YJI3 →
Q7TQN9	—	0.961	Q7TQN9 →
Q6H2Y3	—	0.961	Q6H2Y3 →
LPAR1	Lysophosphatidic acid receptor 1	0.961	landscape →
Q9I8K8	—	0.960	Q9I8K8 →
P79945	—	0.960	P79945 →
P34311	—	0.960	P34311 →
Q8SWR3	—	0.960	Q8SWR3 →
O54798	—	0.960	O54798 →
Q01717	—	0.959	Q01717 →
P35371	—	0.959	P35371 →
Q9EQ31	—	0.958	Q9EQ31 →
Q8BZ39	—	0.958	Q8BZ39 →
MC5R	Melanocortin receptor 5	0.958	landscape →
Q75Z89	—	0.958	Q75Z89 →
Q9EQQ4	—	0.958	Q9EQQ4 →
HTR2C	5-hydroxytryptamine receptor 2C	0.958	landscape →
LPAR3	Lysophosphatidic acid receptor 3	0.958	landscape →