Sugi Predict

Sugi Predict / Compounds / SCHEMBL114553

SCHEMBL114553

SCHEMBL114553

COC(=O)c1cnc(C)c(F)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ATM Q13315 1/20 0.51
▸ MAPK1 P28482 2/20 0.47
▸ KDM4E B2RXH2 4/20 0.45
▸ L3MBTL1 Q9Y468 2/20 0.45
▸ POLB P06746 2/20 0.44
▸ TDP1 Q9NUW8 2/20 0.44
▸ LMNA P02545 1/20 0.44
▸ GAA P10253 1/20 0.44
▸ NFKB1 P19838 1/20 0.44
▸ XDH P47989 1/20 0.44
▸ GFER P55789 1/20 0.44
▸ NFKB2 Q00653 1/20 0.44
▸ RELA Q04206 1/20 0.44
▸ FUT7 Q11130 1/20 0.44
▸ PSMD14 O00487 1/20 0.43
▸ ALDH1A1 P00352 2/20 0.42
▸ CYP1A2 P05177 1/20 0.41
▸ CYP3A4 P08684 1/20 0.41
▸ CYP2C9 P11712 1/20 0.41
▸ CYP2C19 P33261 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30574354 1.00 ATM (0.51) ATMMAPK1KDM4EL3MBTL1POLB
SCHEMBL16215530 0.84 ABL1 (0.35) ATML3MBTL1TDP1ALDH1A1CYP2C9
SCHEMBL29220843 0.84 KDM4E (0.50) ATMMAPK1KDM4EL3MBTL1POLB
SCHEMBL4538933 0.84 MAPK1 (0.49) ATMMAPK1KDM4EL3MBTL1POLB
SCHEMBL31444518 0.84 MAPK1 (0.49) ATMMAPK1KDM4EL3MBTL1POLB
SCHEMBL17295856 0.83 CYP2C9 (0.53) TDP1LMNACYP1A2CYP3A4CYP2C9
SCHEMBL24215426 0.82 MAPK1 (0.47) ATMMAPK1KDM4EL3MBTL1POLB
SCHEMBL335203 0.81 ATM (0.55) ATMMAPK1KDM4EL3MBTL1POLB
SCHEMBL1063745 0.81 MAPK1 (0.46) ATMMAPK1KDM4EL3MBTL1POLB
SCHEMBL20601801 0.81 PDGFRB (0.48) ATMMAPK1KDM4EL3MBTL1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260102395-A1 INHIBITING HISTONE DEACETYLASE 6 EIKONIZO THERAPEUTICS, INC. (US) 2026-04-16 — — US disclosed
US-12590084-B2 Oxadiazole HDAC6 inhibitors and uses thereof EIKONIZO THERAPEUTICS, INC. (US) 2026-03-31 — — US disclosed
US-20260055090-A1 OXADIAZOLE HDAC6 INHIBITORS AND USES THEREOF EIKONIZO THERAPEUTICS, INC. (US) 2026-02-26 — — US disclosed
US-20250250263-A1 INHIBITING HISTONE DEACETYLASE 6 (HDAC6) EIKONIZO THERAPEUTICS, INC. (US) 2025-08-07 — — US disclosed
US-20250230166-A1 OXADIAZOLE HDAC6 INHIBITORS AND USES THEREOF EIKONIZO THERAPEUTICS, INC. (US) 2025-07-17 — — US disclosed
CN-119451678-A Inhibition of histone deacetylase 6 (HDAC 6) 艾科尼佐治疗股份有限公司 2025-02-14 — — CN disclosed
EP-4504191-A1 INHIBITING HISTONE DEACETYLASE 6 (HDAC6) Eikonizo Therapeutics, Inc. (US) 2025-02-12 — — EP disclosed
EP-4504190-A1 OXADIAZOLE HDAC6 INHIBITORS AND USES THEREOF Eikonizo Therapeutics, Inc. (US) 2025-02-12 — — EP disclosed
CN-119212707-A Oxadiazole HDAC6 inhibitors and uses thereof 艾科尼佐治疗股份有限公司 2024-12-27 — — CN disclosed
CN-118525011-A Morpholinyl quinazoline compound, preparation method and application thereof 上海璎黎药业有限公司 2024-08-20 — — CN disclosed
WO-2013071693-A1 OXADIAZOLE COMPOUND AND PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF 上海交通大学 (CN) 2013-05-23 — — WO disclosed
US-8362249-B2 CXCR3 receptor antagonists BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-01-29 — — US disclosed
US-8362249-B2 CXCR3 receptor antagonists BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-01-29 — — US disclosed
US-8362249-B2 CXCR3 receptor antagonists BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-01-29 — — US disclosed
EP-2424858-A1 CXCR3 RECEPTOR ANTAGONISTS Boehringer Ingelheim International GmbH (DE) 2012-03-07 — — EP disclosed
WO-2010126851-A1 CXCR3 RECEPTOR ANTAGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-11-04 — — WO disclosed
WO-2010126851-A1 CXCR3 RECEPTOR ANTAGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-11-04 — — WO disclosed
US-20100273781-A1 CXCR3 RECEPTOR ANTAGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-10-28 — — US disclosed
US-20100273781-A1 CXCR3 RECEPTOR ANTAGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-10-28 — — US disclosed
US-20100273781-A1 CXCR3 RECEPTOR ANTAGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-10-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250230166-A1 OXADIAZOLE HDAC6 INHIBITORS AND USES THEREOF HDAC6, HDAC1, HDAC11 ATM 1313/4885MAPK1 2989/4885KDM4E 2674/4885
US-12590084-B2 Oxadiazole HDAC6 inhibitors and uses thereof HDAC6, HDAC1, HDAC9 ATM 397/4885MAPK1 919/4885KDM4E 1491/4885
US-20260055090-A1 OXADIAZOLE HDAC6 INHIBITORS AND USES THEREOF HDAC6, HDAC1, CTTN ATM 1268/4885MAPK1 587/4885KDM4E 3413/4885
US-20260102395-A1 INHIBITING HISTONE DEACETYLASE 6 HDAC6, HDAC1, HDAC8 ATM 1456/4885MAPK1 2091/4885KDM4E 866/4885
US-20100273781-A1 CXCR3 RECEPTOR ANTAGONISTS CXCR3, CXCR1, CXCR2 ATM 3084/4885MAPK1 1970/4885KDM4E 3738/4885
US-20250250263-A1 INHIBITING HISTONE DEACETYLASE 6 (HDAC6) HDAC6, HDAC1, HDAC9 ATM 966/4885MAPK1 2274/4885KDM4E 1593/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.