CXCR3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL335753	1.00	20/20
SCHEMBL433439	1.00	20/20
SCHEMBL433440	0.71	20/20
SCHEMBL116699	0.61	20/20
SCHEMBL178063	0.60	20/20
SCHEMBL114030	0.58	20/20
SCHEMBL163491	0.57	20/20
SCHEMBL113954	0.57	20/20
SCHEMBL165135	0.55	20/20
SCHEMBL116694	0.55	20/20
SCHEMBL114062	0.54	20/20
SCHEMBL114550	0.54	20/20
SCHEMBL165386	0.54	20/20
SCHEMBL167571	0.54	20/20
SCHEMBL164933	0.53	20/20
SCHEMBL165663	0.53	20/20
SCHEMBL165338	0.53	20/20
SCHEMBL166028	0.53	20/20
SCHEMBL162241	0.52	20/20
SCHEMBL166781	0.52	20/20

Clinical trials — most relevant to CXCR3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Leronlimab in Patients With Coronavirus Disease 2019 (COVID-19) With Need for Mechanical Ventilation or Extracorporeal Membrane Oxygenation	PHASE3	SUSPENDED
Leronlimab in Moderately Ill Patients With COVID-19 Pneumonia	PHASE3	SUSPENDED
Safety and Efficacy Study of Intravenous Immunoglobulin to Treat Japanese Encephalitis	PHASE2	COMPLETED
Safety Study of a Chemokine Receptor (CXCR4) Antagonist in Multiple Myeloma Patients	PHASE1/PHASE2	COMPLETED
Pembrolizumab and Chemotherapy Neoadjuvant/Adjuvant of NSCLC	PHASE2	ACTIVE_NOT_RECRUITING
Celecoxib, Recombinant Interferon Alfa-2b, and Rintatolimod in Treating Patients With Colorectal Cancer Metastatic to the Liver	PHASE2	COMPLETED
First Time in Human Study With GSK1325756	PHASE1	COMPLETED
Application of 68Ga-Pentixafor PET/CT for Thymoma	EARLY_PHASE1	UNKNOWN
Evaluating Urinary CXCL10 for Enhanced Detection of Acute Rejection in Kidney Transplant Patients With Low DD-CFDNA	nan	RECRUITING
Value of Various Chemokines in the Detection and Follow up of RCC	nan	UNKNOWN
Comparative Study Between Alzheimer's and Multi-infarct Dementia	nan	UNKNOWN
The Role of MMPs in the CXCL12-Induced Invasion of Laryngeal and Hypopharyngeal Squamous Cell Carcinoma	nan	UNKNOWN
C-X-C Chemokine Receptor 4 in Chronic Lymphocytic Leukemia	nan	UNKNOWN
Tregs CD25 CXCL9 in Vitiligo	nan	UNKNOWN
The Role of SDF-1/CXCR4 in Metastasis of Oral Squamous Cell Carcinoma	nan	UNKNOWN
Level of Expression and Prognostic Value of CXCL4, CXCL4L1 and CXCR3 in Renal Cell Carcinoma	nan	COMPLETED
The Influence of Extracorporeal Photopheresis on Skin Sclerosis	nan	COMPLETED
Preliminary Study of CXCL3 As a Biomarker of Diabetic Kidney Disease	nan	COMPLETED
Activation and Recruitment of GIL During Hp Infection	nan	UNKNOWN
Involvement of Skeletal Muscle Fibrocytes in sarcOpenia in Patients With Chronic ObstRuctive Pulmonary Disease	nan	COMPLETED
The Effect of a Gluten Free Diet on the Permeability of the Blood Brain Barrier in Patients With CIS	nan	COMPLETED
Circular RNA and Chemerin in Breast Cancer Patient	nan	UNKNOWN
Genetic Polymorphism Associated With Coronary Heart Disease Susceptibility and Variability of Clopidogrel Response	nan	ACTIVE_NOT_RECRUITING
The Role of Cxcr4Hi neutrOPhils in InflueNza	nan	RECRUITING
Nivolumab in mRCC Patients: Treg Function, T-cell Access and NK Interactions to Predict and Improve Efficacy	nan	COMPLETED
Lung-Resident Memory Th2 Cells in Asthma	nan	ACTIVE_NOT_RECRUITING
Measuring the Healthy Pediatric Inflammatory Response to Vaccination.	nan	ENROLLING_BY_INVITATION
Interactions Between Immune Cells of Intestinal Mucosa or Peripheral Blood With the Extracellular Matrix in Inflammatory Bowel Disease (IBD)	nan	UNKNOWN
Detection of Circulating Biomarkers of Immunogenic Cell Death	nan	COMPLETED
The Role of Stromal Cell-Derived Factor-1 (SDF-1)/CXC Chemokine Receptor 4 (CXCR4) in Metastasis of Laryngeal and Hypopharyngeal Squamous Cell Carcinoma	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a CXCR3 binder may also engage these)

Protein	Name	Similarity
O88410	—	0.998	O88410 →
Q5KSK8	—	0.996	Q5KSK8 →
Q5MD61	—	0.995	Q5MD61 →
Q867B2	—	0.995	Q867B2 →
Q9JII9	—	0.992	Q9JII9 →
LTB4R	Leukotriene B4 receptor 1	0.974	landscape →
P48748	—	0.967	P48748 →
Q3T181	—	0.966	Q3T181 →
Q7SZP9	—	0.965	Q7SZP9 →
Q8HZN9	—	0.963	Q8HZN9 →
Q9R0Q2	—	0.961	Q9R0Q2 →
A0T2N3	—	0.961	A0T2N3 →
Q95L01	—	0.960	Q95L01 →
O88855	—	0.960	O88855 →
Q8HZP1	—	0.959	Q8HZP1 →
Q3BCU0	—	0.958	Q3BCU0 →
Q8HZP3	—	0.957	Q8HZP3 →
Q9JJL9	—	0.955	Q9JJL9 →
Q8HZP2	—	0.955	Q8HZP2 →
BDKRB1	B1 bradykinin receptor	0.955	landscape →
Q924U0	—	0.955	Q924U0 →
F7EQ49	—	0.954	F7EQ49 →
Q6UNA4	—	0.952	Q6UNA4 →
Q9BDQ5	—	0.952	Q9BDQ5 →
Q61125	—	0.952	Q61125 →
LTB4R2	Leukotriene B4 receptor 2	0.952	landscape →
Q9JL21	—	0.951	Q9JL21 →
CCR10	C-C chemokine receptor type 10	0.947	landscape →
GPER1	G-protein coupled estrogen receptor 1	0.947	landscape →
GPR35	G-protein coupled receptor 35	0.946	landscape →