Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.53 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11448416 | 0.97 | LMNA (0.58) | HRH3LMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL14578201 | 0.89 | CHRNB4 (0.62) | HRH3HTTCHRNB4CHRNA3 | |
| SCHEMBL14578202 | 0.86 | CHRNB4 (0.65) | HRH3CHRNB4CHRNA3 | |
| SCHEMBL11656348 | 0.85 | CHRNB4 (0.73) | HRH3CHRNB4CHRNA3KMT2A | |
| SCHEMBL11448054 | 0.85 | KDM4E (0.59) | HRH3CHRNB4CHRNA3 | |
| SCHEMBL9238637 | 0.85 | CHRNB4 (0.72) | CHRNB4CHRNA3 | |
| SCHEMBL11448270 | 0.85 | HRH3 (0.55) | HRH3CHRNB4CHRNA3 | |
| SCHEMBL9238640 | 0.85 | CHRNB4 (0.72) | CHRNB4CHRNA3 | |
| SCHEMBL11457944 | 0.84 | CHRNB4 (0.74) | HRH3CHRNB4CHRNA3 | |
| SCHEMBL11447890 | 0.84 | KDM4E (0.55) | CHRNB4CHRNA3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4225608-A | ANTIDEPRESSANTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-09-30 | — | — | US | disclosed |