Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9225532 | 0.91 | MMP8 (0.54) | MMP8SMN1; SMN2PIN1MEN1KMT2A | |
| SCHEMBL7418448 | 0.88 | MMP8 (0.51) | MMP8SMN1; SMN2PIN1MEN1KMT2A | |
| SCHEMBL10869302 | 0.85 | MMP8 (0.51) | MMP8SMN1; SMN2TP53PIN1MEN1 | |
| SCHEMBL27814580 | 0.85 | SMN1; SMN2 (0.59) | MMP8SMN1; SMN2TP53PIN1MEN1 | |
| SCHEMBL16477715 | 0.84 | MMP8 (0.54) | MMP8SMN1; SMN2PIN1MEN1KMT2A | |
| SCHEMBL13751893 | 0.84 | MMP8 (0.54) | MMP8SMN1; SMN2PIN1MEN1KMT2A | |
| SCHEMBL7057177 | 0.84 | BRD4 (0.53) | SMN1; SMN2TP53MEN1KMT2APOLB | |
| SCHEMBL7056451 | 0.84 | SMN1; SMN2 (0.49) | SMN1; SMN2TP53MEN1KMT2ANPC1 | |
| SCHEMBL3240811 | 0.83 | MMP8 (0.50) | MMP8SMN1; SMN2TP53PIN1MEN1 | |
| SCHEMBL3236310 | 0.83 | KMT2A (0.56) | MEN1KMT2ATSHRALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4218452-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-08-19 | — | — | US | disclosed |
| US-4159329-A | BLOCKING AGENTS, ANTAGONISTS, ANTIHISTAMINES | SMITHKLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-06-26 | — | — | US | disclosed |
| US-4145546-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-03-20 | — | — | US | disclosed |