Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | PGK1 | P00558 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1145865 | 0.79 | CSNK1A1 (0.36) | CSNK1A1CLK4HTTGLAMAPK1 | |
| SCHEMBL1145552 | 0.77 | CSNK1A1 (0.39) | CSNK1A1CLK4KMT2AARKDM4E | |
| SCHEMBL27826456 | 0.75 | CSNK1A1 (0.55) | CSNK1A1CLK4HTTGLAMAPK1 | |
| SCHEMBL24596942 | 0.73 | CSNK1A1 (0.52) | CSNK1A1CLK4HTTMEN1KMT2A | |
| SCHEMBL23025666 | 0.71 | MEN1 (0.36) | CSNK1A1CLK4HTTGLAMEN1 | |
| SCHEMBL9884987 | 0.68 | ADORA2A (0.47) | CSNK1A1CLK4HTTMAPK1MEN1 | |
| SCHEMBL13082566 | 0.68 | AR (0.37) | HTTGLAMAPK1MEN1KMT2A | |
| SCHEMBL13986698 | 0.67 | MEN1 (0.35) | HTTGLAMAPK1MEN1KMT2A | |
| SCHEMBL2517644 | 0.67 | MEN1 (0.39) | CSNK1A1CLK4HTTMAPK1MEN1 | |
| SCHEMBL8397028 | 0.67 | KMT2A (0.42) | CSNK1A1CLK4HTTMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110028455-A1 | Indole-substituted 3-cyanopyridines As Kinase Inhibitors | WYETH LLC (US) | 2011-02-03 | — | — | US | disclosed |
| EP-2229376-A1 | INDOLE-SUBSTITUTED 3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009076571-A1 | INDOLE-SUBSTITUTED 3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028455-A1 | Indole-substituted 3-cyanopyridines As Kinase Inhibitors | CNKSR1, CSNK1G3, GRK3 | CSNK1A1 21/4885CLK4 364/4885HTT 4745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.