Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.60 |
| ▸ | AKR1C3 | P42330 | 10/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 10/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22242339 | 0.79 | CYP2A6 (0.45) | AKR1B1MAPTALDH1A1HSD17B10HIF1A | |
| SCHEMBL11470668 | 0.78 | AKR1B1 (0.57) | AKR1B1AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL11780974 | 0.78 | AKR1B1 (0.57) | AKR1B1AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL11270273 | 0.75 | AKR1B1 (1.00) | AKR1B1AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL11744482 | 0.75 | AKR1B1 (0.53) | AKR1B1AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL28540948 | 0.74 | AKR1B1 (0.58) | AKR1B1AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL1882695 | 0.74 | AKR1B1 (0.55) | AKR1B1AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL12431128 | 0.74 | AKR1B1 (0.69) | AKR1B1AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL1217681 | 0.74 | AKR1B1 (0.69) | AKR1B1AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL10025981 | 0.74 | AKR1B1 (0.69) | AKR1B1AKR1C3AKR1C2PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4207241-A | ANALGESICS, ANTIPYRETICS, ANTIINFLAMMATORY AGENTS AND ANTIPRURITIC AGENTS | SYNTEX CORPORATION (US) | 1980-06-10 | — | — | US | disclosed |
| US-4097674-A | ANTIINFLAMMATORY, ANTIPYRETIC, ANTIPRURITIC AGENTS, ANALGESICS | SYNTEX CORPORATION (US) | 1978-06-27 | — | — | US | disclosed |
| US-4051233-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, ANTIPRURITIC | SYNTEX CORPORATION (US) | 1977-09-27 | — | — | US | disclosed |
| US-4001301-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIPYRETICS, ANTI-PRURITIC | SYNTEX CORPORATION (PM) | 1977-01-04 | — | — | US | disclosed |
| US-3998966-A | Anti-inflammatory, analgesic, anti-pyretic and anti-pruritic 6-substituted 2-naphthyl acetic acid derivative-containing compositions and methods of use thereof | SYNTEX CORPORATION (PM) | 1976-12-21 | — | — | US | disclosed |
| US-3980699-A | ANTIINFLAMMATORY, ANALGESICS, ANTIPYRETIC, ANTIPRURITIC | SYNTEX CORPORATION (PM) | 1976-09-14 | — | — | US | disclosed |
| US-3978124-A | ANALGESIC, ANTIPYRETIC | SYNTEX CORPORATION (PM) | 1976-08-31 | — | — | US | disclosed |
| US-3978116-A | ANALGESIC, ANTIPYRETIC | SYNTEX CORPORATION (PM) | 1976-08-31 | — | — | US | disclosed |